Low oxygen availability, a condition known as hypoxia, is a common feature of various
pathologies including stroke, ischemic heart disease, and cancer. Hypoxia adaptation …

The membrane of the endoplasmic reticulum (ER) of nucleated human cells harbors the
protein translocon, which facilitates membrane integration or translocation of almost every …

During cotranslational translocation, the signal peptide of a nascent chain binds Sec61
translocon to initiate protein transport through the endoplasmic reticulum (ER) membrane …

The rough endoplasmic reticulum (ER) of nucleated human cells has crucial functions in
protein biogenesis, calcium (Ca2+) homeostasis, and signal transduction. Among the …

Cancer stem cells (CSCs) play major roles in tumor initiation, progression, and resistance to
cancer therapy. Several CSC markers have been studied in head and neck squamous cell …

Patients with malignant tumors frequently suffer during disease progression from a
syndrome referred to as cancer cachexia (CaCax): CaCax includes skeletal muscle atrophy …

Locally advanced head and neck squamous cell carcinomas (HNSCC) have limited
prognosis due to frequent treatment failure. Currently, TNM-classification and human …

SOX2 copy number and mRNA expression were analysed to examine the clinical
significance of SOX2 activation in HNSCC. Gene expression signatures reflecting SOX2 …

SOX2 is a pleiotropic nuclear transcription factor with major roles in stem cell biology and in
development. Over the last 10 years SOX2 has also been implicated as a lineage-specific …

The human SEC62 gene is located on chromosome 3q, was characterized as a tumor driver
gene and is found to be overexpressed in an ever-growing number of tumors, particularly …