Neutrophils at the crossroads of innate and adaptive immunity

C Rosales - Journal of Leucocyte Biology, 2020 - academic.oup.com
Neutrophils are the most abundant leukocytes in blood. From the circulation, they are quickly
mobilized to sites of inflammation and/or infection. At the affected tissues, neutrophils display …

Interleukin-8: A chemokine at the intersection of cancer plasticity, angiogenesis, and immune suppression

K Fousek, LA Horn, C Palena - Pharmacology & therapeutics, 2021 - Elsevier
Tumor progression relies on the ability of cancer cells to effectively invade surrounding
tissues and propagate. Among the many mechanisms that contribute to tumor progression is …

The predictive role of NLR, d-NLR, MLR, and SIRI in COVID-19 mortality

C Citu, F Gorun, A Motoc, I Sas, OM Gorun, B Burlea… - Diagnostics, 2022 - mdpi.com
(1) Background: Since its discovery, COVID-19 has caused more than 256 million cases,
with a cumulative death toll of more than 5.1 million, worldwide. Early identification of …

Neutrophil extracellular traps in homeostasis and disease

H Wang, SJ Kim, Y Lei, S Wang, H Wang… - … and Targeted Therapy, 2024 - nature.com
Neutrophil extracellular traps (NETs), crucial in immune defense mechanisms, are
renowned for their propensity to expel decondensed chromatin embedded with inflammatory …

Neutrophil degranulation, plasticity, and cancer metastasis

F Mollinedo - Trends in immunology, 2019 - cell.com
Neutrophils are the first responders to inflammation and infection. Recently, an elevated
neutrophil-to-lymphocyte ratio has generally become a prognostic indicator of poor overall …

Control of innate immune response by biomaterial surface topography, energy, and stiffness

JO Abaricia, N Farzad, TJ Heath, J Simmons… - Acta Biomaterialia, 2021 - Elsevier
As the focus of implantable biomaterials has shifted from bioinert implants to bioactive
designs, recent research has highlighted the complex interactions between cell physiologic …

Multiple roles for chemokines in neutrophil biology

A Capucetti, F Albano, R Bonecchi - Frontiers in immunology, 2020 - frontiersin.org
Chemokines are recognized as the most critical mediators for selective neutrophil
recruitment during inflammatory conditions. Furthermore, they are considered fundamental …

The regulatory roles of neutrophils in adaptive immunity

Y Li, W Wang, F Yang, Y Xu, C Feng, Y Zhao - Cell Communication and …, 2019 - Springer
Neutrophils have long been considered as cells playing a crucial role in the immune
defence against invading pathogens. Accumulating evidence strongly supported the direct …

Guidelines for the use of flow cytometry and cell sorting in immunological studies

A Cossarizza, HD Chang, A Radbruch… - European journal of …, 2021 - Wiley Online Library
The third edition of Flow Cytometry Guidelines provides the key aspects to consider when
performing flow cytometry experiments and includes comprehensive sections describing …

Periodontitis pathogen Porphyromonas gingivalis promotes pancreatic tumorigenesis via neutrophil elastase from tumor-associated neutrophils

Q Tan, X Ma, B Yang, Y Liu, Y Xie, X Wang, W Yuan… - Gut …, 2022 - Taylor & Francis
Intratumor microbiome shapes the immune system and influences the outcome of various
tumors. Porphyromonas gingivalis (P. gingivalis), the keystone periodontal pathogen, is …