Immunomodulatory effects of dopamine in inflammatory diseases

Y Feng, Y Lu - Frontiers in immunology, 2021 - frontiersin.org
Dopamine (DA) receptor, a significant G protein-coupled receptor, is classified into two
families: D1-like (D1 and D5) and D2-like (D2, D3, and D4) receptor families, with further …

[HTML][HTML] Dopamine D3 receptor: A neglected participant in Parkinson Disease pathogenesis and treatment?

P Yang, JS Perlmutter, TLS Benzinger, JC Morris… - Ageing research …, 2020 - Elsevier
Parkinson disease (PD) is a neurodegenerative disorder characterized by motor and non-
motor symptoms which relentlessly and progressively lead to substantial disability and …

Can C-reactive protein inform antidepressant medication selection in depressed outpatients? Findings from the CO-MED trial

MK Jha, A Minhajuddin, BS Gadad, T Greer… - …, 2017 - Elsevier
Objective Currently, no valid measures inform treatment selection for depressed patients.
Whether C-reactive protein (CRP) in particular and two other acute phase reactants …

Dopamine D2 receptor restricts astrocytic NLRP3 inflammasome activation via enhancing the interaction of β-arrestin2 and NLRP3

J Zhu, Z Hu, X Han, D Wang, Q Jiang, J Ding… - Cell Death & …, 2018 - nature.com
Astrocytes are involved in the neuroinflammation of neurodegenerative diseases, such as
Parkinson's disease (PD). Among the numerous inflammatory cytokines, interleukin-1β (IL …

Specific immune status in Parkinson's disease at different ages of onset

J Tian, SB Dai, SS Jiang, WY Yang, YQ Yan… - npj Parkinson's …, 2022 - nature.com
Recent evidence suggests that innate and adaptive immunity play a crucial role in
Parkinson's disease (PD). However, studies regarding specific immune cell classification in …

Targeting NLRP3 inflammasome in the treatment of CNS diseases

BZ Shao, Q Cao, C Liu - Frontiers in molecular neuroscience, 2018 - frontiersin.org
Central nervous system (CNS) is one of the largest killers of people's health all over the
world. The overactivation of the immune and inflammatory responses is considered as an …

[HTML][HTML] The involvement of NLRP3 inflammasome in the treatment of neurodegenerative diseases

YS Feng, ZX Tan, LY Wu, F Dong, F Zhang - Biomedicine & …, 2021 - Elsevier
In an ageing society, neurodegenerative diseases have attracted attention because of their
high incidence worldwide. Despite extensive research, there is a lack of conclusive insights …

[HTML][HTML] Dopamine, a co-regulatory component, bridges the central nervous system and the immune system

M Li, L Zhou, X Sun, Y Yang, C Zhang, T Wang… - Biomedicine & …, 2022 - Elsevier
Dopamine (DA) is a crucial neurotransmitter that plays an important role in maintaining
physiological function in human body. In the past, most studies focused on the relationship …

Personalized antidepressant selection and pathway to novel treatments: clinical utility of targeting inflammation

MK Jha, MH Trivedi - International journal of molecular sciences, 2018 - mdpi.com
Major depressive disorder (MDD) is a chronic condition that affects one in six adults in the
US during their lifetime. The current practice of antidepressant medication prescription is a …

The dopamine transporter: An unrecognized nexus for dysfunctional peripheral immunity and signaling in Parkinson's Disease

P Mackie, J Lebowitz, L Saadatpour, E Nickoloff… - Brain, behavior, and …, 2018 - Elsevier
The second-most common neurodegenerative disease, Parkinson's Disease (PD) has three
hallmarks: dysfunctional dopamine transmission due, at least in part, to dopamine neuron …