1.1. Discovery of the Phospholipase A2 Superfamily Phospholipases represent one of the
earliest enzyme activities to be identified and studied, and the phospholipase A2 (PLA2) …

Pulmonary fibrosis is a highly heterogeneous and lethal pathological process with limited
therapeutic options. Although research on the pathogenesis of pulmonary fibrosis has …

The group IV phospholipase A 2 (PLA 2) family is comprised of six intracellular enzymes
(GIVA,-B,-C,-D,-E, and-F) commonly referred to as cytosolic PLA 2 (cPLA 2) α,-β,-γ,-δ,-ε, and …

Mammalian genomes encode genes for more than 30 phospholipase A2s (PLA2s) or
related enzymes, which are subdivided into several classes including low-molecular-weight …

Prostaglandins, leukotrienes, platelet-activating factor, lysophosphatidic acid, sphingosine 1-
phosphate, and endocannabinoids, collectively referred to as lipid mediators, play pivotal …

Despite its disadvantages, the bleomycin animal model remains the best available
experimental tool for studying disease pathogenesis and testing of novel pharmaceutical …

Apoptosis is essential for clearance of potentially injurious inflammatory cells and
subsequent efficient resolution of inflammation. Here we report that human neutrophils …

In respiratory diseases, there is an increased expression of multiple inflammatory proteins in
the respiratory tract, including cytokines, chemokines, and adhesion molecules …

Lysophosphatidylcholine (LPC) and lysophosphatidic acid (LPA), the most prominent
lysoglycerophospholipids, are emerging as a novel class of inflammatory lipids, joining …

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrotic form of diffuse lung
disease occurring mainly in older adults. Increased lysophosphatidic acid (LPA) …