This review discusses a set of instrumental and computational methods that are used to
characterize hydrated forms of APIs (active pharmaceutical ingredients). The focus has been …

In the introduction to this review the complex chemistry of solid-state pharmaceutical
compounds is summarized. It is also explained why the density functional theory (DFT) …

The crystallization mechanisms of organic molecules in solution are not well-understood.
The mechanistic scenarios where crystalline order evolves directly from the molecularly …

Solvents for spherical agglomerates preparation are usually selected according to the
Lifshitz–van der Waals acid–base theory with negative adhesion free energies. However …

Induction time measurement experiments for etoricoxib (ETR) were carried out in four
solvents. The results suggest the crystal nucleation of ETR becomes increasingly more …

In this paper, a comprehensive study of the solid and solution chemistry of etoricoxib (ETR)
was conducted through the combined experimental identification and theoretical calculation …

Brain tumors are still the deadliest among all types of cancer even after decades of
extensive research. Glioblastoma is the most common and aggressive form of primary …

Non-covalent interactions are critical components in the synthetic toolbox to modulate self-
assembly processes and molecular recognition. Hydrogen bonding is most commonly …

Background Polymorphism is that a substance exists into more than two crystalline forms
with different molecular arrangements and/or conformations. It has been reported that the …

In drug development, evaluating the stability of the hydrate is particularly important because
changes in the hydration state could cause alterations of the physicochemical properties. In …