Mechanisms of regulation of the chemokine-receptor network
The interactions of chemokines with their G protein-coupled receptors promote the migration
of leukocytes during normal immune function and as a key aspect of the inflammatory …
of leukocytes during normal immune function and as a key aspect of the inflammatory …
Chemokine: receptor structure, interactions, and antagonism
SJ Allen, SE Crown, TM Handel - Annu. Rev. Immunol., 2007 - annualreviews.org
Chemokines are critical mediators of cell migration during routine immune surveillance,
inflammation, and development. Chemokines bind to G protein–coupled receptors and …
inflammation, and development. Chemokines bind to G protein–coupled receptors and …
[HTML][HTML] Regulation of CXCR4 signaling
JM Busillo, JL Benovic - Biochimica et Biophysica Acta (BBA) …, 2007 - Elsevier
The chemokine receptor CXCR4 belongs to the large superfamily of G protein-coupled
receptors, and is directly involved in a number of biological processes including …
receptors, and is directly involved in a number of biological processes including …
Structural basis of CXCR4 sulfotyrosine recognition by the chemokine SDF-1/CXCL12
CT Veldkamp, C Seibert, FC Peterson… - Science …, 2008 - science.org
Stem cell homing and breast cancer metastasis are orchestrated by the chemokine stromal
cell–derived factor 1 (SDF-1) and its receptor CXCR4. Here, we report the nuclear magnetic …
cell–derived factor 1 (SDF-1) and its receptor CXCR4. Here, we report the nuclear magnetic …
Monomeric and dimeric CXCL12 inhibit metastasis through distinct CXCR4 interactions and signaling pathways
LJ Drury, JJ Ziarek, S Gravel… - Proceedings of the …, 2011 - National Acad Sciences
Chemokines and chemokine receptors are extensively and broadly involved in cancer
metastasis. Previously, we demonstrated that epigenetic silencing of the chemokine …
metastasis. Previously, we demonstrated that epigenetic silencing of the chemokine …
Cell surface engineering to enhance mesenchymal stem cell migration toward an SDF-1 gradient
Mesenchymal stem cell (MSC) therapy for the treatment of myocardial infarction (MI) has
shown considerable promise in clinical trials. A billion MSCs need to be administered for …
shown considerable promise in clinical trials. A billion MSCs need to be administered for …
New paradigms in chemokine receptor signal transduction: Moving beyond the two-site model
Chemokine receptor (CKR) signaling forms the basis of essential immune cellular functions,
and dysregulated CKR signaling underpins numerous disease processes of the immune …
and dysregulated CKR signaling underpins numerous disease processes of the immune …
Tyrosine sulfation: an increasingly recognised post-translational modification of secreted proteins
The post-translational sulfation of tyrosine residues occurs in numerous secreted and
integral membrane proteins and, in many cases, plays a crucial role in controlling the …
integral membrane proteins and, in many cases, plays a crucial role in controlling the …
Structural basis of the interaction between chemokine stromal cell-derived factor-1/CXCL12 and its G-protein-coupled receptor CXCR4
Y Kofuku, C Yoshiura, T Ueda, H Terasawa… - Journal of Biological …, 2009 - ASBMB
The chemokine stromal cell-derived factor-1 (SDF-1/CXCL12) and its G-protein-coupled
receptor (GPCR) CXCR4 play fundamental roles in many physiological processes, and …
receptor (GPCR) CXCR4 play fundamental roles in many physiological processes, and …
Recombinant expression of selectively sulfated proteins in Escherichia coli
CC Liu, PG Schultz - Nature biotechnology, 2006 - nature.com
Although tyrosine sulfation is a post-translational modification widespread across
multicellular eukaryotes, its biological functions remain largely unknown. This is in part due …
multicellular eukaryotes, its biological functions remain largely unknown. This is in part due …