Heart failure with preserved ejection fraction (HFpEF), a major public health problem that is
rising in prevalence, is associated with high morbidity and mortality and is considered to be …

The potential benefits of supplemental nutrients and dietary interventions against
cardiovascular morbidity and mortality have been extensively investigated throughout the …

Ventricular–arterial coupling (VAC) plays a major role in the physiology of cardiac and aortic
mechanics, as well as in the pathophysiology of cardiac disease. VAC assessment …

Importance There are few effective treatments for heart failure with preserved ejection
fraction (HFpEF). Short-term administration of inorganic nitrite or nitrate preparations has …

Heart failure with preserved ejection fraction (HFpEF) involves multiple pathophysiological
mechanisms, which result in the heterogeneous phenotypes that are evident clinically, and …

Background: Single measurements of left ventricular filling pressure at rest lack sensitivity for
identifying heart failure with preserved ejection fraction (HFpEF) in patients with dyspnea on …

Nitric oxide is an endogenously formed gas that acts as a signaling molecule in the human
body. The signaling functions of nitric oxide are accomplished through two primer …

The hallmark symptom of chronic heart failure (HF) is severe exercise intolerance. Impaired
perfusive and diffusive O2 transport are two of the major determinants of reduced physical …

Three sentinel parameters of aerobic performance are the maximal oxygen uptake (), critical
power (CP) and speed of the kinetics following exercise onset. Of these, the latter is …

Measures of interaction between the left ventricle (LV) and arterial system (ventricular–
arterial coupling) are important but under-recognised cardiovascular phenotypes in heart …