Microglia activation is observed in various neurodegenerative diseases. Recent advances in
single-cell technologies have revealed that these reactive microglia were with high spatial …

Neurodegenerative diseases are a common cause of morbidity and cognitive impairment in
older adults. Most clinicians who care for the elderly are not trained to diagnose these …

Prions are proteins that adopt alternative conformations that become self-propagating; the
PrPSc prion causes the rare human disorder Creutzfeldt–Jakob disease (CJD). We report …

Multiple-system atrophy is a neurodegenerative disease characterized by progressive
autonomic failure, parkinsonism, and cerebellar and pyramidal tract symptoms. Glial …

Background Multiple system atrophy is a rare, fatal neurodegenerative disorder with
symptoms of autonomic failure plus parkinsonism, cerebellar ataxia, or both. We report …

Progressive supranuclear palsy (PSP) is a clinical syndrome comprising supranuclear palsy,
postural instability, and mild dementia. Neuropathologically, PSP is defined by the …

Background: Parkinson disease is a common neurodegenerative disease. The racial, sex,
age, and geographic distributions of Parkinson disease in the US are unknown. Methods …

Background The prevalence of progressive supranuclear palsy (PSP) and multiple system
atrophy (MSA) in the general population is unknown. Clinicopathological studies of patients …

The population of the United States is aging, and an ever-increasing number of Americans
are afflicted with neurodegenerative diseases. Because the pathogenesis of many of these …

Objective: Parkinson disease (PD) may affect the autonomic nervous system and may cause
constipation; however, few studies have explored constipation preceding the motor onset of …