The life of eukaryotic cells requires the transport of lipids between membranes, which are
separated by the aqueous environment of the cytosol. Vesicle-mediated traffic along the …

Lipid droplets are dynamic organelles that store neutral lipids, serve the metabolic needs of
cells, and sequester lipids to prevent lipotoxicity and membrane damage. Here we review …

Selective macroautophagy (hereafter referred to as autophagy) describes a process in
which cytosolic material is engulfed in a double membrane organelle called an …

As the autophagosome forms, its membrane surface area expands rapidly, while its volume
is kept low. Protein-mediated transfer of lipids from another organelle to the autophagosome …

Autophagy is a cellular homeostasis mechanism that fuels the proliferation and survival of
advanced cancers by degrading and recycling organelles and proteins. Preclinical studies …

During autophagy, rapid membrane assembly expands small phagophores into large
double-membrane autophagosomes. Theoretical modeling predicts that the majority of …

Liver fibrosis is characterized by the excessive deposition and accumulation of extracellular
matrix components, mainly collagens, and occurs in response to a broad spectrum of …

Membrane-bound organelles allow cells to traffic cargo and separate and regulate
metabolic pathways. While many organelles are generated by the growth and division of …

Autophagy–the lysosomal degradation of cytoplasm–plays a central role in cellular
homeostasis and protects cells from potentially harmful agents that may accumulate in the …

Autophagosome biogenesis requires a localized perturbation of lipid membrane dynamics
and a unique protein-lipid conjugate. Autophagy-related (ATG) proteins catalyze this …