Inflammasomes are protein complexes of the innate immune system that initiate
inflammation in response to either exogenous pathogens or endogenous danger signals …

Inflammasomes are molecular platforms that assemble upon sensing various intracellular
stimuli. Inflammasome assembly leads to activation of caspase 1, thereby promoting the …

NLRP3 inflammasome can be widely found in epithelial cells and immune cells. The NOD-
like receptors (NLRs) family member NLRP3 contains a central nucleotide-binding and …

Programmed cell death is regulated by evolutionarily conserved pathways that play critical
roles in development and the immune response. A newly recognized pathway for …

PANoptosis, a new research hotspot at the moment, is a cell death pattern in which
pyroptosis, apoptosis, and necroptosis all occur in the same cell population. In essence …

Abstract Tumor Necrosis Factor (TNF), initially known for its tumor cytotoxicity, is a potent
mediator of inflammation, as well as many normal physiological functions in homeostasis …

A complex mucosal barrier protects as the first line of defense the surface of the healthy
intestinal tract from adhesion and invasion by luminal microorganisms. In this review, we …

NLRP3, a member of nucleotide-binding domain-(NOD) like receptor family, can be found in
large varieties of immune and non-immune cells. Upon activation, the NLRP3, apoptosis …

Background The NLR family, pyrin domain containing 3 (NLRP 3) inflammasome is an
interleukin (IL)‐1β and IL‐18 cytokine processing complex that is activated in inflammatory …

Background The proinflammatory cytokines interleukin 1β (IL-1β) and IL-18 are central
players in the pathogenesis of inflammatory bowel disease (IBD). In response to a variety of …