Pharma [e] cology: how the gut microbiome contributes to variations in drug response
KR Trepka, CA Olson, V Upadhyay… - Annual Review of …, 2024 - annualreviews.org
Drugs represent our first, and sometimes last, line of defense for many diseases, yet despite
decades of research we still do not fully understand why a given drug works in one patient …
decades of research we still do not fully understand why a given drug works in one patient …
Non-SCFA microbial metabolites associated with fiber fermentation and host health
Dietary fiber is degraded by commensal gut microbes to yield host-beneficial short-chain
fatty acids (SCFAs), but personalized responses to fiber supplementation highlight a role for …
fatty acids (SCFAs), but personalized responses to fiber supplementation highlight a role for …
[HTML][HTML] Microbiome-based therapeutics for Parkinson's disease
AM Hamilton, IN Krout, AC White, TR Sampson - Neurotherapeutics, 2024 - Elsevier
Recent experimental and clinical data demonstrate a significant dysregulation of the gut
microbiome in individuals with Parkinson's disease (PD). With an immense influence on all …
microbiome in individuals with Parkinson's disease (PD). With an immense influence on all …
Dysbiosis of the gut microbiota and its effect on α-synuclein and prion protein misfolding: consequences for neurodegeneration
Abnormal behavior of α-synuclein and prion proteins is the hallmark of Parkinson's disease
(PD) and prion illnesses, respectively, being complex neurological disorders. A primary …
(PD) and prion illnesses, respectively, being complex neurological disorders. A primary …
Metagenomic Analysis Reveals Large‐Scale Disruptions of the Gut Microbiome in Parkinson's Disease
A Metcalfe‐Roach, MS Cirstea, AC Yu… - Movement …, 2024 - Wiley Online Library
Background Parkinson's disease (PD) has been consistently linked to alterations within the
gut microbiome. Objective Our goal was to identify microbial features associated with PD …
gut microbiome. Objective Our goal was to identify microbial features associated with PD …
Advice to People with Parkinson's in My Clinic: Probiotics and Prebiotics
There is increasing evidence that microbial-based therapies can be useful in people with
Parkinson's disease (PD). In this viewpoint, we provide a state-of-the-art review of the …
Parkinson's disease (PD). In this viewpoint, we provide a state-of-the-art review of the …
[PDF][PDF] Gut-directed therapy in Parkinson's disease
L Benvenuti, C Di Salvo, G Bellini… - Frontiers in …, 2024 - researchgate.net
Parkinson's disease (PD) is a frequent, slow-progressing neurodegenerative disease that
affects over six million individuals worldwide with a growing economic impact on society …
affects over six million individuals worldwide with a growing economic impact on society …
Neurotoxicology of dopamine: victim or assailant?
Since the identification of dopamine as a neurotransmitter in the mid-20th century,
investigators have examined the regulation of dopamine homeostasis at a basic biological …
investigators have examined the regulation of dopamine homeostasis at a basic biological …
A prebiotic diet intervention can restore faecal short chain fatty acids in Parkinson's Disease yet fails to restore the gut microbiome homeostasis
Despite extensive research, current treatment of Parkinson's Disease (PD) remains
symptomatic and disease modifying approaches are urgently required. A promising …
symptomatic and disease modifying approaches are urgently required. A promising …
Dietary L-3, 4-dihydroxyphenylalanine (L-DOPA) augments cuticular melanization in Anopheles mosquitos while reducing their lifespan and malaria parasite burden
L-3, 4-dihydroxyphenylalanine (L-DOPA), a naturally occurring tyrosine derivative, is
prevalent in environments that include mosquito habitats, potentially serving as part of their …
prevalent in environments that include mosquito habitats, potentially serving as part of their …