Update on findings about sudden sensorineural hearing loss and insight into its pathogenesis

S Yamada, J Kita, D Shinmura, Y Nakamura… - Journal of Clinical …, 2022 - mdpi.com
Sudden sensorineural hearing loss (SSNHL) is routinely encountered and is one of the most
common emergent diseases in otolaryngology clinics. However, the etiology of SSNHL …

[HTML][HTML] Intratympanic corticosteroids for sudden sensorineural hearing loss

SK Plontke, C Meisner, S Agrawal… - The Cochrane …, 2022 - ncbi.nlm.nih.gov
Background Idiopathic sudden sensorineural hearing loss (ISSNHL) is common, and
defined as a sudden decrease in sensorineural hearing sensitivity of unknown aetiology …

A single dose of AC102 restores hearing in a guinea pig model of noise-induced hearing loss to almost prenoise levels

H Rommelspacher, S Bera… - Proceedings of the …, 2024 - National Acad Sciences
Although sudden sensorineural hearing loss (SSNHL) is a serious condition, there are
currently no approved drugs for its treatment. Nevertheless, there is a growing …

Intratympanic vs systemic corticosteroids in first-line treatment of idiopathic sudden sensorineural hearing loss: a systematic review and meta-analysis

C Mirian, T Ovesen - JAMA Otolaryngology–Head & Neck …, 2020 - jamanetwork.com
Importance To our knowledge, evidence-based recommendations on the intratympanic vs
systemic administration of corticosteroids for the treatment of idiopathic sudden …

High-dose glucocorticoids for the treatment of sudden hearing loss

SK Plontke, M Girndt, C Meisner, I Fischer… - NEJM …, 2023 - evidence.nejm.org
Background Systemic glucocorticoids are commonly used for primary therapy of idiopathic
sudden sensorineural hearing loss (ISSNHL). However, the comparative effectiveness and …

[HTML][HTML] The NLRP3 inflammasome as a target for sensorineural hearing loss

GE Gregory, KJ Munro, KN Couper… - Clinical …, 2023 - Elsevier
Sensorineural hearing loss is the most common type of hearing loss in adults and occurs
due to damage of the inner ear caused by a range of factors including ageing, excessive …

The role of Nrf2 in hearing loss

D Li, H Zhao, ZK Cui, G Tian - Frontiers in pharmacology, 2021 - frontiersin.org
Hearing loss is a major unresolved problem in the world, which has brought a heavy burden
to society, economy, and families. Hair cell damage and loss mediated by oxidative stress …

Idiopathic sudden sensorineural hearing loss: A critique on corticosteroid therapy

DH Murray, PA Fagan, DK Ryugo - Hearing Research, 2022 - Elsevier
Idiopathic sudden sensorineural hearing loss (ISSNHL) is a condition affecting 5-30 per
100,000 individuals with the potential to significantly reduce one's quality of life. The true …

A prognostic model to predict hearing recovery in patients with idiopathic sudden onset sensorineural hearing loss

R Mandavia, N Joshi, G Hannink… - … –Head & Neck …, 2024 - jamanetwork.com
Importance The prognosis of idiopathic sudden onset sensorineural hearing loss (iSSNHL)
is uncertain, which creates challenges in clinical decision-making for ear, nose, and throat …

Hyperbaric oxygenation as adjunctive therapy in the treatment of sudden sensorineural hearing loss

D Olex-Zarychta - International journal of molecular sciences, 2020 - mdpi.com
Sudden sensorineural hearing loss seems to become a serious social health problem in
modern societies. According to the World Health Organization (WHO) reports, adult-onset …