Paracellular permeability and tight junction regulation in gut health and disease

A Horowitz, SD Chanez-Paredes, X Haest… - Nature Reviews …, 2023 - nature.com
Epithelial tight junctions define the paracellular permeability of the intestinal barrier.
Molecules can cross the tight junctions via two distinct size-selective and charge-selective …

The immunology and immunopathology of COVID-19

M Merad, CA Blish, F Sallusto, A Iwasaki - Science, 2022 - science.org
Considerable research effort has been made worldwide to decipher the immune response
triggered upon severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections …

Pathological sequelae of long-haul COVID

S Mehandru, M Merad - Nature immunology, 2022 - nature.com
The world continues to contend with successive waves of coronavirus disease 2019 (COVID-
19), fueled by the emergence of viral variants. At the same time, persistent, prolonged and …

Molecular mechanism of interaction between SARS-CoV-2 and host cells and interventional therapy

Q Zhang, R Xiang, S Huo, Y Zhou, S Jiang… - Signal transduction and …, 2021 - nature.com
The pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infection has resulted in an unprecedented setback …

[HTML][HTML] Colonization of the live biotherapeutic product VE303 and modulation of the microbiota and metabolites in healthy volunteers

M Dsouza, R Menon, E Crossette, SK Bhattarai… - Cell Host & Microbe, 2022 - cell.com
Manipulation of the gut microbiota via fecal microbiota transplantation (FMT) has shown
clinical promise in diseases such as recurrent Clostridioides difficile infection (rCDI) …

Mucosal immunity: The missing link in comprehending SARS-CoV-2 infection and transmission

MW Russell, J Mestecky - Frontiers in immunology, 2022 - frontiersin.org
SARS-CoV-2 is primarily an airborne infection of the upper respiratory tract, which on
reaching the lungs causes the severe acute respiratory disease, COVID-19. Its first contact …

Innate immunity, cytokine storm, and inflammatory cell death in COVID-19

R Karki, TD Kanneganti - Journal of Translational Medicine, 2022 - Springer
The innate immune system serves as the first line of defense against invading pathogens;
however, dysregulated innate immune responses can induce aberrant inflammation that is …

Investigating the possible mechanisms of autonomic dysfunction post-COVID-19

M Jammoul, J Naddour, A Madi, MA Reslan… - Autonomic …, 2023 - Elsevier
Patients with long COVID suffer from many neurological manifestations that persist for 3
months following infection by SARS-CoV-2. Autonomic dysfunction (AD) or dysautonomia is …

A comprehensive SARS-CoV-2 and COVID-19 review, Part 2: host extracellular to systemic effects of SARS-CoV-2 infection

SA Narayanan, DA Jamison Jr, JW Guarnieri… - European Journal of …, 2024 - nature.com
COVID-19, the disease caused by SARS-CoV-2, has caused significant morbidity and
mortality worldwide. The betacoronavirus continues to evolve with global health implications …

[HTML][HTML] Dealing with a mucosal viral pandemic: lessons from COVID-19 vaccines

V Mouro, A Fischer - Mucosal immunology, 2022 - Elsevier
The development and deployment of vaccines against COVID-19 demonstrated major
successes in providing immunity and preventing severe disease and death. Yet SARS-CoV …