Natural compounds in sex hormone-dependent cancers: The role of triterpenes as therapeutic agents
C Şoica, M Voicu, R Ghiulai, C Dehelean… - Frontiers in …, 2021 - frontiersin.org
Sex hormone-dependent cancers currently contribute to the high number of cancer-related
deaths worldwide. The study and elucidation of the molecular mechanisms underlying the …
deaths worldwide. The study and elucidation of the molecular mechanisms underlying the …
In Vitro and In Silico Studies of Antimicrobial Saponins: A Review
J Li, V Monje-Galvan - Processes, 2023 - mdpi.com
Antibiotics are important drugs for the treatment of microbial infections and related diseases.
However, due to the abuse of antibiotics, drug resistance has become a serious and urgent …
However, due to the abuse of antibiotics, drug resistance has become a serious and urgent …
Establishing a link between the chemical composition and biological activities of Gladiolus italicus Mill. from the Turkish flora utilizing in vitro, in silico and network …
Objectives Five solvent extracts (n-hexane, ethyl acetate, ethanol, ethanol/water (70%), and
water) of Gladiolus italicus Mill. from Turkey were evaluated for chemical and biological …
water) of Gladiolus italicus Mill. from Turkey were evaluated for chemical and biological …
Design, synthesis and molecular modeling of novel aryl carboximidamides and 3-aryl-1, 2, 4-oxadiazoles derived from indomethacin as potent anti-inflammatory iNOS …
The development of NSAIDs/iNOS inhibitor hybrids is a new strategy for the treatment of
inflammatory diseases by suppression of the overproduction of PGE 2 and NO. A novel …
inflammatory diseases by suppression of the overproduction of PGE 2 and NO. A novel …
Utilization of cyanopyridine in design and synthesis of first-in-class anticancer dual acting PIM-1 kinase/HDAC inhibitors
AKA Bass, ESM Nageeb, MS El-Zoghbi… - Bioorganic …, 2022 - Elsevier
Herein, we report design and synthesis of twenty-one dual PIM-1/HDAC inhibitors utilizing 3-
cyanopyridines as a novel cap moiety linked with aliphatic/aromatic linker bearing carboxylic …
cyanopyridines as a novel cap moiety linked with aliphatic/aromatic linker bearing carboxylic …
Novel chalcone/aryl carboximidamide hybrids as potent anti-inflammatory via inhibition of prostaglandin E2 and inducible NO synthase activities: design, synthesis …
TS Ibrahim, AH Moustafa, AJ Almalki… - Journal of enzyme …, 2021 - Taylor & Francis
Two series of chalcone/aryl carboximidamide hybrids 4a–f and 6a–f were synthesised and
evaluated for their inhibitory activity against iNOS and PGE2. The most potent derivatives …
evaluated for their inhibitory activity against iNOS and PGE2. The most potent derivatives …
Design and synthesis of novel pyrazolo [3, 4-d] pyrimidin-4-one bearing quinoline scaffold as potent dual PDE5 inhibitors and apoptotic inducers for cancer therapy
PDE5 targeting represents a new and promising strategy for apoptosis induction and
inhibition of tumor cell growth due to its over-expression in diverse types of human …
inhibition of tumor cell growth due to its over-expression in diverse types of human …
Phosphoinositide 3‐Kinase Inhibitors from Gladiolus Segetum Ker‐Gawl Corms Supported by Network Pharmacology
B Khalaf Mahmoud, MF Abdelwahab… - Chemistry & …, 2024 - Wiley Online Library
Abstract Gladiolus segetum Ker‐Gawl corms total extract exhibited remarkable in vitro anti‐
proliferative effects against panel of cancer cell lines; including human colon carcinoma …
proliferative effects against panel of cancer cell lines; including human colon carcinoma …
[PDF][PDF] Molecular docking study reveals the potential repurposing of histone deacetylase inhibitors against Covid-19
MFA Mohamed, GEDA Abuo-Rahma… - International Journal …, 2020 - researchgate.net
The outburst of new coronavirus (COVID-19) infections, firstly appeared in Wuhan in 2019,
has massively expanded to the whole world. At the end of March 2020, the rapid spread of …
has massively expanded to the whole world. At the end of March 2020, the rapid spread of …
Synthesis, antimicrobial studies, and molecular docking of some new dihydro-1, 3, 4-thiadiazole and pyrazole derivatives derived from dithiocarbazates
AH Moustafa, DH Ahmed, MTM El-Wassimy… - Synthetic …, 2021 - Taylor & Francis
Abstract A series of 3-acetyl-2-aryl-5-methylthio-2, 3-dihydro-1, 3, 4-thiadiazoles 3a–g, N-(4-
acetyl-5-aryl-4, 5-dihydro-1, 3, 4-thiadiazol-2-yl) acetamide derivatives 5a–e and spiro …
acetyl-5-aryl-4, 5-dihydro-1, 3, 4-thiadiazol-2-yl) acetamide derivatives 5a–e and spiro …