Over the last several decades, our understanding of the genetic variation, pathophysiology,
and complications of the hemolytic anemia associated with red cell pyruvate kinase …

Red cell pyruvate kinase (PK) deficiency is the most frequent enzyme abnormality of the
glycolytic pathway causing hereditary non‐spherocytic haemolytic anaemia. The degree of …

Pyruvate kinase (PK) is a key enzyme for the glycolytic pathway and carbon metabolism in
general. On the basis of the relevance and enormous diverse properties of this enzyme, this …

Pyruvate kinase (PK) deficiency is the most common cause of hereditary nonspherocytic
hemolytic anemia. The prevalence of this deficiency is unknown, though some estimates …

Red cell pyruvate kinase (PK) deficiency is the most frequent enzyme abnormality of
glycolysis causing chronic non-spherocytic haemolytic anaemia. The disease is transmitted …

Pyruvate kinase deficiency is the most frequent enzyme abnormality of the Embden–
Meyerhof pathway causing hereditary non-spherocytic haemolytic anaemia. The degree of …

Pyruvate kinase (PK) deficiency is known as being the most common cause of chronic
nonspherocytic hemolytic anemia (CNSHA). Clinical PK deficiency is transmitted as an …

Mutations in the PKLR gene lead to pyruvate kinase (PK) deficiency, causing chronic
hemolytic anemia secondary to reduced red cell energy, which is crucial for maintenance of …

Accurate diagnosis of rare inherited anaemias is challenging, requiring a series of complex
and expensive laboratory tests. Targeted next‐generation‐sequencing (NGS) has been …

Molecular abnormalities of erythroenzymopathies associated with hereditary hemolytic
anemia have been determined by means of molecular biology. Pyruvate kinase (PK) …