Alzheimer′ s disease (AD) is the leading cause of dementia and cognitive decline in the
elderly. Brain tissue changes indicate that the two main proteins involved in AD are amyloid …

The complement system plays a key role in innate immunity, inflammation, and coagulation.
The system is delicately balanced by negative regulatory mechanisms that modulate the …

Primary Sertoli cells isolated from mouse testes survive when transplanted across
immunological barriers and protect cotransplanted allogeneic and xenogeneic cells from …

Background Neuropathic pain is a debilitating disease caused by damage or diseases of the
somatosensory nervous system. Previous research has indicated potential associations …

Rheumatoid arthritis (RA) is the world's most common autoimmune disease mainly
characterized by a chronic inflammation of multiple synovial joints. Rheumatologists now …

The serpin C1 inhibitor (C1-INH) is the only regulator of classical complement activation as
well as the major regulator of the contact system. Its importance is demonstrated by …

Neurochemical differential diagnosis between Alzheimer's disease and other dementias is
currently based on CSF biomarkers. Here, we report a method by which potential …

The classical pathway of complement is crucial to the immune system, but it also contributes
to inflammatory diseases when dysregulated. Binding of the C1 complex to ligands activates …

Purpose Age-related macular degeneration (AMD) and cuticular drusen (CD), a clinical
subtype of AMD, have been linked to genetic variants in the complement factor H (CFH) …

Sertoli cells constitute the structural framework in testis and provide an immune-privileged
environment for germ cells. Induced pluripotent stem cells (iPS cells) resemble embryonic …