Astrocytes are neural cells of ectodermal, neuroepithelial origin that provide for homeostasis
and defense of the central nervous system (CNS). Astrocytes are highly heterogeneous in …

The S100 protein family consists of 24 members functionally distributed into three main
subgroups: those that only exert intracellular regulatory effects, those with intracellular and …

Abstract In 1994, the “danger model” argued that adaptive immune responses are driven
rather by molecules released upon tissue damage than by the recognition of “strange” …

The inflammatory hypothesis of schizophrenia (SZ) posits that inflammatory processes and
neural–immune interactions are involved in its pathogenesis, and may underpin some of its …

ABSTRACT RAGE is a key molecule in the onset and sustainment of the inflammatory
response. New studies indicate that RAGE might represent a new link between the innate …

S100 is a multigenic family of non-ubiquitous Ca2+-modulated proteins of the EF-hand type
expressed in vertebrates exclusively and implicated in intracellular and extracellular …

S100 proteins are calcium-binding proteins that regulate several processes associated with
Alzheimer's disease (AD) but whose contribution and direct involvement in disease …

The Ca2+-binding protein of the EF-hand type, S100B, exerts both intracellular and
extracellular functions. Recent studies have provided more detailed information concerning …

S100, a multigenic family of non‐ubiquitous Ca2+‐modulated proteins of the EF‐hand type
expressed in vertebrates exclusively, has been implicated in intracellular and extracellular …

S100B is a calcium‐binding peptide produced mainly by astrocytes that exert paracrine and
autocrine effects on neurons and glia. Some knowledge has been acquired from in vitro and …