In health technology assessment (HTA), population‐adjusted indirect comparisons (PAICs)
are increasingly considered to adjust for the difference in the target population between …

Network meta‐analysis (NMA) is an extension of pairwise meta‐analysis (PMA) which
combines evidence from trials on multiple treatments in connected networks. NMA delivers …

Objective To generate comparative efficacy evidence of belimumab versus anifrolumab in
SLE that can inform treatment practices. Methods The SLE Responder Index (SRI)-4 …

In a recent issue of the Journal; Remiro‐Azócar et al. introduce a new method to adjust for
population difference between two trials; when the individual patient data (IPD) are only …

In evidence synthesis, effect modifiers are typically described as variables that induce
treatment effect heterogeneity at the individual level, through treatment‐covariate …

The SCHOLAR-2 retrospective study highlighted poor overall survival (OS) with standard of
care (SOC) regimens among patients with relapsed/refractory (R/R) mantle cell lymphoma …

Background Anchored covariate-adjusted indirect comparisons inform reimbursement
decisions where there are no head-to-head trials between the treatments of interest, there is …

We are thankful for the opportunity to comment on the paper by Remiro-Azócar which
discusses conditional and marginal estimands in the context of indirect comparisons for …

Disagreement remains on what the target estimand should be for population-adjusted
indirect treatment comparisons. This debate is of central importance for policy-makers and …

I congratulate the authors on an interesting article and thank the
Editorsfortheopportunitytodiscussthework. Themanuscript under discussion devises an …