NF-κB signaling in macrophages: dynamics, crosstalk, and signal integration
MG Dorrington, IDC Fraser - Frontiers in immunology, 2019 - frontiersin.org
The nuclear factor-κB (NF-κB) signaling pathway is one of the best understood immune-
related pathways thanks to almost four decades of intense research. NF-κB signaling is …
related pathways thanks to almost four decades of intense research. NF-κB signaling is …
Integration of innate immune signaling
The last decades of research in innate immunology have revealed a multitude of sensing
receptors that evaluate the presence of microorganisms or cellular damage in tissues. In the …
receptors that evaluate the presence of microorganisms or cellular damage in tissues. In the …
Investigating the role of TNF-α and IFN-γ activation on the dynamics of iNOS gene expression in LPS stimulated macrophages
T Salim, CL Sershen, EE May - PloS one, 2016 - journals.plos.org
Macrophage produced inducible nitric oxide synthase (iNOS) is known to play a critical role
in the proinflammatory response against intracellular pathogens by promoting the …
in the proinflammatory response against intracellular pathogens by promoting the …
Applications of non-invasive neuromodulation for the management of disorders related to COVID-19
Background: Novel coronavirus disease (COVID-19) morbidity is not restricted to the
respiratory system, but also affects the nervous system. Non-invasive neuromodulation may …
respiratory system, but also affects the nervous system. Non-invasive neuromodulation may …
Selective autophagy of the adaptor TRIF regulates innate inflammatory signaling
Defective autophagy is linked to diseases such as rheumatoid arthritis, lupus and
inflammatory bowel disease (IBD). However, the mechanisms by which autophagy limits …
inflammatory bowel disease (IBD). However, the mechanisms by which autophagy limits …
Synthetic Toll-like receptor 4 (TLR4) and TLR7 ligands as influenza virus vaccine adjuvants induce rapid, sustained, and broadly protective responses
PH Goff, T Hayashi, L Martínez-Gil, M Corr… - Journal of …, 2015 - Am Soc Microbiol
Current vaccines against influenza virus infection rely on the induction of neutralizing
antibodies targeting the globular head of the viral hemagglutinin (HA). Protection against …
antibodies targeting the globular head of the viral hemagglutinin (HA). Protection against …
TLR cross-talk confers specificity to innate immunity
Cross-talk within the innate immune pathways is highly complex and contains many
unknowns. Here, we discuss the different combinations of PAMPs, together with the …
unknowns. Here, we discuss the different combinations of PAMPs, together with the …
IFIT1 exerts opposing regulatory effects on the inflammatory and interferon gene programs in LPS-activated human macrophages
SP John, J Sun, RJ Carlson, B Cao, CJ Bradfield… - Cell reports, 2018 - cell.com
Activation of the TLR4 signaling pathway by lipopolysaccharide (LPS) leads to induction of
both inflammatory and interferon-stimulated genes, but the mechanisms through which …
both inflammatory and interferon-stimulated genes, but the mechanisms through which …
The molecular mechanisms of TLR‐signaling cooperation in cytokine regulation
Innate immune cells recognize pathogens through pattern recognition receptors (PRRs),
and activation of PRRs induces downstream signaling pathways to mount appropriate …
and activation of PRRs induces downstream signaling pathways to mount appropriate …
[HTML][HTML] Effective chemoimmunotherapy by co-delivery of doxorubicin and immune adjuvants in biodegradable nanoparticles
CG Da Silva, MGM Camps, TMWY Li, L Zerrillo… - Theranostics, 2019 - ncbi.nlm.nih.gov
Chemoimmunotherapy is an emerging combinatorial modality for the treatment of cancers
resistant to common first-line therapies, such as chemotherapy and checkpoint blockade …
resistant to common first-line therapies, such as chemotherapy and checkpoint blockade …