A Combined Experimental and Computational Study of Novel Benzotriazinone Carboxamides as Alpha-Glucosidase Inhibitors

Z Khalid, SS Shafqat, HA Ahmad, MA Munawar… - Molecules, 2023 - mdpi.com
Diabetes is a chronic metabolic disorder of the endocrine system characterized by persistent
hyperglycemia appears due to the deficiency or ineffective use of insulin. The glucose level …

Experimental and Computational Analysis of Newly Synthesized Benzotriazinone Sulfonamides as Alpha-Glucosidase Inhibitors

Z Khalid, MA Alnuwaiser, HA Ahmad, SS Shafqat… - Molecules, 2022 - mdpi.com
Diabetes mellitus is a chronic metabolic disorder in which the pancreas secretes insulin but
the body cells do not recognize it. As a result, carbohydrate metabolism causes …

Bifunctional Phosphine Ligand-Enabled Gold(I)-Catalyzed O-Nucleophilic Addition of N-Hydroxybenzo[1,2,3]-triazin-4(3H)-ones to Alkynes Followed by [3,3] …

Y Xu, K Zheng, B Zhou, H Jin, Y Liu - The Journal of Organic …, 2020 - ACS Publications
We describe a gold (I)-catalyzed tandem O-nucleophilic addition/[3, 3]-rearrangement
reaction of N-hydroxybenzo [1, 2, 3]-triazin-4 (3 H)-ones with alkynes enabled by a biphenyl …

Chemistry and Biological Activity of [1, 2, 3]-Benzotriazine Derivatives

GM Ziarani, M Mostofi, N Lashgari - Current Organic Chemistry, 2018 - ingentaconnect.com
[1, 2, 3]-Benzotriazines represent an interesting category of heterocyclic compounds.
Various synthetic methods, key reactions and biological aspects have been highlighted. In …

Cyclization of thiosemicarbazide derivative: As a source of novel synthesis of some azoles and azines

MHM Abd El‐Azim, MG Assy, MI Khalil… - Journal of Heterocyclic …, 2020 - Wiley Online Library
In our study, we aimed to synthesize novel, some biologically active compounds, Azoles and
Azines derivatives, that to be nitrogen‐containing heterocycles, and have their diverse …

Predictive biological activity of newly synthesized hydrazone compounds derived from indomethacin

NA Hussien, HY Hussien… - Journal of Wildlife and …, 2023 - wildlife-biodiversity.com
New derivatives of hydrazone have been successfully created, specifically 2-(1-(Aryl)-5-
methoxy-2-methyl-1H-indol-3-yl)-N'-(2-chlorobenzylidene) acetohydrazide. The …

Novel one-pot methods for the synthesis of fluorescent amino acids

R McGrory - 2023 - theses.gla.ac.uk
The aim of this PhD was to utilise novel methodology for the synthesis of fluorescent amino
acids. The first section describes the development of a mild, one-pot diazotisation and …