After the hurricane: Anti-COVID-19 drugs development, molecular mechanisms of action and future perspectives

HO Khalifa, YM Al Ramahi - International Journal of Molecular Sciences, 2024 - mdpi.com
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is a new coronavirus in
the Coronaviridae family. The COVID-19 pandemic, caused by SARS-CoV-2, has …

Paxlovid as a potential treatment for long COVID

MW McCarthy - Expert Opinion on Pharmacotherapy, 2023 - Taylor & Francis
ABSTRACT Introduction On 31 July 2023, the United States Department of Health and
Human Services announced the formation of the Office of Long COVID Research and …

Development and Validation of a High-Performance Liquid Chromatography with Tandem Mass Spectrometry (HPLC-MS/MS) Method for Quantification of Major …

T Komarov, P Karnakova, O Archakova… - Biomedicines, 2023 - mdpi.com
Molnupiravir is an antiviral drug against viral RNA polymerase activity approved by the FDA
for the treatment of COVID-19, which is metabolized to β-D-N4-hydroxycytidine (NHC) in …

[HTML][HTML] Molnupiravir compared to nirmatrelvir/ritonavir for COVID-19 in high-risk patients with haematological malignancy in Europe. A matched-paired analysis from …

J Salmanton-García, F Marchesi, P Koehler… - International Journal of …, 2023 - Elsevier
Introduction Molnupiravir and nirmatrelvir/ritonavir are antivirals used to prevent progression
to severe SARS-CoV-2 infections and decrease hospitalisation and mortality rates …

Phytoestrogens: Chemistry, potential health benefits, and their medicinal importance

VP Chavda, AZ Chaudhari, PC Balar… - Phytotherapy …, 2024 - Wiley Online Library
Phytoestrogens, also known as xenoestrogens, are secondary metabolites derived from
plants that have similar structures and biological effects as human estrogens. These …

How do we change our approach to COVID with the changing face of disease?

V Apostolopoulos, J Feehan… - Expert Review of Anti …, 2024 - Taylor & Francis
Introduction The emergence of SARS-CoV-2 triggered a global health emergency, causing>
7 million deaths thus far. Limited early knowledge spurred swift research, treatment, and …

Multi-spectroscopic, calorimetric and molecular dynamics evaluation on non-classical intercalation of antiviral drug Molnupiravir with DNA

K Pavithra, R Durga Priyadharshini… - Journal of …, 2023 - Taylor & Francis
The interaction of an antiviral drug Molnupiravir (MOL) with calf thymus DNA (CT-DNA) was
investigated using a series of biophysical techniques. A significant hyperchromism with a …

Regulatory processes involved in clinical trials and intellectual property rights around vaccine development

N Desai, S Pande, AD Gholap, D Rana… - … for Infectious and …, 2024 - Elsevier
This chapter explores the critical intersection of regulatory processes and intellectual
property rights (IPR) within the context of vaccine development. With the ongoing global …

White targeted chromatographic screening method of Molnupiravir and its metabolite with degradation kinetics characterization and in-silico toxicity

SI Aboras, AA Megahed, F El-Yazbi, HM Maher - Scientific Reports, 2023 - nature.com
SARS-CoV-2 virus triggered a worldwide crisis, with world nations putting up massive efforts
to halt its spread. Molnupiravir (MLN) was the first oral, direct-acting antiviral drug approved …

COVID-19-Triggered Acute Liver Failure and Rhabdomyolysis: A Case Report and Review of the Literature

Y Matsuki, T Sugihara, T Kihara, T Kawakami, T Kitaura… - Viruses, 2023 - mdpi.com
COVID-19 is primarily known for its respiratory tract involvement, often leading to severe
pneumonia and exacerbation of underlying diseases. However, emerging evidence …