Cell death is critical for the development and homeostasis of almost all multicellular
organisms. Moreover, its dysregulation leads to diverse disease states. Historically …

Pancreatic cancer is an aggressive cancer with a poor prognosis. Metabolic abnormalities
are one of the hallmarks of pancreatic cancer, and pancreatic cancer cells can adapt to …

Copper and other trace metals are essential for life. However, it is important that these
metals are present at the right amount in cells. Too little metal can impair the function of …

Metal ion homeostasis is fundamental for life. Specifically, transition metals iron, manganese
and zinc play a pivotal role in mitochondrial metabolism and energy generation, anti …

Ferroptosis is an oxidative form of iron-dependent cell death characterized by the
accumulation of lipid peroxides on membranes. Iron and lipids containing polyunsaturated …

Gastric cancer remains one of the most common deadly diseases and lacks effective
targeted therapies. In the present study, we confirmed that the signal transducer and …

Cell death resistance represents a hallmark of cancer. Recent studies have identified
metabolic cell death as unique forms of regulated cell death resulting from an imbalance in …

Regulated cell death (RCD), also known as programmed cell death (PCD), plays a critical
role in various biological processes, such as tissue injury/repair, development, and …

Elevated levels of plasma-free fatty acids and oxidative stress have been identified as
putative primary pathogenic factors in endothelial dysfunction etiology, though their roles are …

Zinc oxide nanoparticle (ZnO NP) is one of the most widely used nanomaterial in industrial
and commercial products. Here, we reported hazardous effects of ZnO NP on the …