[HTML][HTML] Microvascular experimentation in the chick chorioallantoic membrane as a model for screening angiogenic agents including from gene-modified cells

DC Kennedy, B Coen, AM Wheatley… - International journal of …, 2021 - mdpi.com
The chick chorioallantoic membrane (CAM) assay model of angiogenesis has been
highlighted as a relatively quick, low cost and effective model for the study of pro-angiogenic …

New ruthenium complexes containing salicylic acid and derivatives induce triple-negative tumor cell death via the intrinsic apoptotic pathway

AE Graminha, C Popolin, JH de Araujo-Neto… - European Journal of …, 2022 - Elsevier
In this work we present the synthesis and characterization of six new ruthenium compounds
with general formulae [Ru (L)(dppb)(bipy)] PF 6 and [Ru (L)(dppe) 2] PF 6 where L= salicylic …

Novel lawsone-containing ruthenium (II) complexes: Synthesis, characterization and anticancer activity on 2D and 3D spheroid models of prostate cancer cells

RA De Grandis, PWS Dos Santos, KM de Oliveira… - Bioorganic …, 2019 - Elsevier
This study describes a series of newly synthesized phosphine/diimine ruthenium complexes
containing the lawsone as bioligand with enhanced cytotoxicity against different cancer …

Ru (II)/amino acid complexes inhibit the progression of breast cancer cells through multiple mechanism-induced apoptosis

F Mello-Andrade, APM Guedes, WC Pires… - Journal of Inorganic …, 2022 - Elsevier
For some cancer subtypes, such as triple-negative breast cancer, there are no specific
therapies, which leads to a poor prognosis associated with invasion and metastases …

Ruthenium (II) salicylate complexes inducing ROS-mediated apoptosis by targeting thioredoxin reductase

J Chen, Y Zhang, X Jie, J She, G Dongye… - Journal of inorganic …, 2019 - Elsevier
Thioredoxin reductase (TrxR), a major component of the thioredoxin system, makes a critical
role in regulating cellular redox signaling and is found to be overexpressed in many human …

Biological activities of pyrazoline-indole based Re (I) carbonyls: DNA interaction, antibacterial, anticancer, ROS production, lipid peroxidation, in vivo and in vitro …

RR Varma, JG Pandya, FU Vaidya, C Pathak… - Chemico-Biological …, 2020 - Elsevier
Hetero mononuclear rhenium (I) metal complexes (IV) using different substituted indole-
pyrazoline based ligands were synthesized and characterized by spectroscopic and …

Heterobimetallic Ru(ii)/Fe(ii) complexes as potent anticancer agents against breast cancer cells, inducing apoptosis through multiple targets

APM Guedes, F Mello-Andrade, WC Pires… - Metallomics, 2020 - academic.oup.com
Antimetastatic activity, high selectivity and cytotoxicity for human tumor cell lines make
ruthenium (ii) complexes attractive for the development of new chemotherapeutic agents for …

IR-780-albumin-based nanocarriers promote tumor regression not only from phototherapy but also by a nonirradiation mechanism

G Capistrano, AA Sousa-Junior, RA Silva… - ACS Biomaterials …, 2020 - ACS Publications
IR-780 iodide is a fluorescent dye with optical properties in the near-infrared region that has
applications in tumor detection and photothermal/photodynamic therapy. This multifunctional …

Anticancer activity and mechanism of bis-pyrimidine based dimetallic Ru (II)(η6-p-cymene) complex in human non-small cell lung cancer via p53-dependent pathway

MZ Bhatti, A Ali, HQ Duong, J Chen… - Journal of inorganic …, 2019 - Elsevier
Non-small cell lung cancer (NSCLC) is the most common cancer worldwide, which is related
with poor prognosis and resistance to chemotherapy. Notably, ruthenium-based complexes …

Determination of in vitro absorption in Caco-2 monolayers of anticancer Ru(II)-based complexes acting as dual human topoisomerase and PARP inhibitors

MS de Camargo, RA De Grandis, MM da Silva… - Biometals, 2019 - Springer
Due to their unique and versatile biochemical properties, ruthenium-based compounds have
emerged as promising anticancer agents. Previous studies showed that three ruthenium (II) …