The clothes make the mRNA: past and present trends in mRNP fashion
Throughout their lifetimes, messenger RNAs (mRNAs) associate with proteins to form
ribonucleoproteins (mRNPs). Since the discovery of the first mRNP component more than 40 …
ribonucleoproteins (mRNPs). Since the discovery of the first mRNP component more than 40 …
The exon junction complex as a node of post-transcriptional networks
HL Hir, J Saulière, Z Wang - Nature reviews Molecular cell biology, 2016 - nature.com
The exon junction complex (EJC) is deposited onto mRNAs following splicing and adopts a
unique structure, which can both stably bind to mRNAs and function as an anchor for diverse …
unique structure, which can both stably bind to mRNAs and function as an anchor for diverse …
RNA-binding proteins: modular design for efficient function
BM Lunde, C Moore, G Varani - Nature reviews Molecular cell biology, 2007 - nature.com
Many RNA-binding proteins have modular structures and are composed of multiple repeats
of just a few basic domains that are arranged in various ways to satisfy their diverse …
of just a few basic domains that are arranged in various ways to satisfy their diverse …
The nonsense-mediated decay RNA surveillance pathway
YF Chang, JS Imam, MF Wilkinson - Annu. Rev. Biochem., 2007 - annualreviews.org
Nonsense-mediated mRNA decay (NMD) is a quality-control mechanism that selectively
degrades mRNAs harboring premature termination (nonsense) codons. If translated, these …
degrades mRNAs harboring premature termination (nonsense) codons. If translated, these …
The RNA recognition motif, a plastic RNA‐binding platform to regulate post‐transcriptional gene expression
C Maris, C Dominguez, FHT Allain - The FEBS journal, 2005 - Wiley Online Library
The RNA recognition motif (RRM), also known as RNA‐binding domain (RBD) or
ribonucleoprotein domain (RNP) is one of the most abundant protein domains in eukaryotes …
ribonucleoprotein domain (RNP) is one of the most abundant protein domains in eukaryotes …
Control of gene expression through the nonsense-mediated RNA decay pathway
A Nickless, JM Bailis, Z You - Cell & bioscience, 2017 - Springer
Nonsense-mediated RNA decay (NMD) was originally discovered as a cellular surveillance
pathway that safeguards the quality of mRNA transcripts in eukaryotic cells. In its canonical …
pathway that safeguards the quality of mRNA transcripts in eukaryotic cells. In its canonical …
Nonsense-mediated decay approaches the clinic
JA Holbrook, G Neu-Yilik, MW Hentze, AE Kulozik - Nature genetics, 2004 - nature.com
Nonsense-mediated decay (NMD) eliminates mRNAs containing premature termination
codons and thus helps limit the synthesis of abnormal proteins. New results uncover a …
codons and thus helps limit the synthesis of abnormal proteins. New results uncover a …
Quality control of eukaryotic mRNA: safeguarding cells from abnormal mRNA function
O Isken, LE Maquat - Genes & development, 2007 - genesdev.cshlp.org
Cells routinely make mistakes. Some mistakes are encoded by the genome and may
manifest as inherited or acquired diseases. Other mistakes occur because metabolic …
manifest as inherited or acquired diseases. Other mistakes occur because metabolic …
[HTML][HTML] Mammalian Staufen1 recruits Upf1 to specific mRNA 3′ UTRs so as to elicit mRNA decay
Abstract Mammalian Staufen (Stau) 1 is an RNA binding protein that is thought to function in
mRNA transport and translational control. Nonsense-mediated mRNA decay (NMD) …
mRNA transport and translational control. Nonsense-mediated mRNA decay (NMD) …
Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA
CBF Andersen, L Ballut, JS Johansen, H Chamieh… - Science, 2006 - science.org
In higher eukaryotes, a multiprotein exon junction complex is deposited on spliced
messenger RNAs. The complex is organized around a stable core, which serves as a …
messenger RNAs. The complex is organized around a stable core, which serves as a …