Dihydropyrimidinones are heterocycles with a pyrimidine moiety in the ring nucleus, which,
in recent decades, have aroused interest in medicinal chemistry due to alleged versatile …

Multicomponent reactions (MCRs) are important transformations, which allow the attainment
of structurally complex derivatives in a single step, starting from three or more compounds …

In this work, we describe the application of a synthetic enzyme (synzyme) as the catalyst to
promote the multicomponent synthesis of isoxazol-5 (4H)-one derivatives. The catalytic …

Herein, we present biological studies on 3, 4-dihydropyrimidin-2 (1H)-ones (DHPMs)
obtained via Biginelli reaction catalyzed by NH4Cl under solvent-free conditions. Until now …

Heterocycles of the isoxazolone class stand out in the pharmaceutical field because they
have numerous biological properties, such as antioxidant, antifungal and antibacterial …

An innovative and environmentally sustainable approach is presented for the synthesis of
cadmium oxide nanoparticles (CdONPs), leveraging the leaf extract of the pigeon pea plant …

Abstract Refluxing of 2, 4, 5-trimethoxyacetophenone with dimethyl formamide dimethyl
acetal (DMF-DMA) in absence of solvent for 12 h resulted in the synthesis of enaminone,(2 …

Dihydropyrimidinones (DHMPs) are six-membered heterocyclic compounds containing two
nitrogen heteroatoms and two keto groups attached to a pyrimidine ring. The DHPMs and …

An accessible, non‐toxic, easy to handle and stock catalyst with high efficiency was
developed in this study for the synthesis of 3, 4‐dihydropyrimidin‐2 (1H)‐ones/thiones …

In this review, the works carried out in Brazil with multicomponent reactions over a period of
30 years were mapped through search in the literature (PubMed, Scopus, and Web of …