Endocrine cells within the pancreatic islets of Langerhans are heterogeneous in terms of
transcriptional profile, protein expression and the regulation of hormone release. Even …

Tendon injuries are common and can dramatically impair patient mobility and productivity,
resulting in a significant socioeconomic burden and reduced quality of life. Because the …

Recent advances in human pluripotent stem cell (hPSC) differentiation protocols have
generated insulin-producing cells resembling pancreatic β cells. While these stem cell …

Impaired function of pancreatic islet cells is a major cause of metabolic dysregulation and
disease in humans. Despite this, it remains challenging to directly link physiological …

Background and aims Molecular evidence of cellular heterogeneity in the human exocrine
pancreas has not been yet established, due to the local concentration and cascade of …

Abstract Purpose of Review To discuss the current understanding of “β cell identity” and
factors underlying altered identity of pancreatic β cells in diabetes, especially in humans …

Although multiple pancreatic islet single-cell RNA-sequencing (scRNA-seq) datasets have
been generated, a consensus on pancreatic cell states in development, homeostasis and …

Findings from the past 10 years have placed the glucagon-secreting pancreatic α-cell centre
stage in the development of diabetes mellitus, a disease affecting almost one in every ten …

This review focuses on the human pancreatic islet—including its structure, cell composition,
development, function, and dysfunction. After providing a historical timeline of key …

Insulin is a life-saving drug for patients with type 1 diabetes; however, even today, no
pharmacotherapy can prevent the loss or dysfunction of pancreatic insulin-producing β cells …