Genome-wide association studies
Genome-wide association studies (GWAS) test hundreds of thousands of genetic variants
across many genomes to find those statistically associated with a specific trait or disease …
across many genomes to find those statistically associated with a specific trait or disease …
[HTML][HTML] The human connectome project: a retrospective
Abstract The Human Connectome Project (HCP) was launched in 2010 as an ambitious
effort to accelerate advances in human neuroimaging, particularly for measures of brain …
effort to accelerate advances in human neuroimaging, particularly for measures of brain …
[HTML][HTML] Sample size, power and effect size revisited: simplified and practical approaches in pre-clinical, clinical and laboratory studies
Sažetak Calculating the sample size in scientific studies is one of the critical issues as
regards the scientific contribution of the study. The sample size critically affects the …
regards the scientific contribution of the study. The sample size critically affects the …
Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence
Intelligence is highly heritable and a major determinant of human health and well-being.
Recent genome-wide meta-analyses have identified 24 genomic loci linked to variation in …
Recent genome-wide meta-analyses have identified 24 genomic loci linked to variation in …
A resource-efficient tool for mixed model association analysis of large-scale data
The genome-wide association study (GWAS) has been widely used as an experimental
design to detect associations between genetic variants and a phenotype. Two major …
design to detect associations between genetic variants and a phenotype. Two major …
Evidence for causal effects of lifetime smoking on risk for depression and schizophrenia: a Mendelian randomisation study
BackgroundSmoking prevalence is higher amongst individuals with schizophrenia and
depression compared with the general population. Mendelian randomisation (MR) can …
depression compared with the general population. Mendelian randomisation (MR) can …
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations
Ulcerative colitis and Crohn's disease are the two main forms of inflammatory bowel disease
(IBD). Here we report the first trans-ancestry association study of IBD, with genome-wide or …
(IBD). Here we report the first trans-ancestry association study of IBD, with genome-wide or …
Identification of 15 genetic loci associated with risk of major depression in individuals of European descent
Despite strong evidence supporting the heritability of major depressive disorder (MDD),
previous genome-wide studies were unable to identify risk loci among individuals of …
previous genome-wide studies were unable to identify risk loci among individuals of …
Increased burden of ultra-rare protein-altering variants among 4,877 individuals with schizophrenia
By analyzing the exomes of 12,332 unrelated Swedish individuals, including 4,877
individuals affected with schizophrenia, in ways informed by exome sequences from 45,376 …
individuals affected with schizophrenia, in ways informed by exome sequences from 45,376 …
TM6SF2 rs58542926 influences hepatic fibrosis progression in patients with non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) is an increasingly common condition, strongly
associated with the metabolic syndrome, that can lead to progressive hepatic fibrosis …
associated with the metabolic syndrome, that can lead to progressive hepatic fibrosis …