Bone-tissue defects affect millions of people worldwide. Despite being common treatment
approaches, autologous and allogeneic bone grafting have not achieved the ideal …

Osteoarthritis comprises several joint disorders characterized by articular cartilage
degeneration and persistent pain, causing disability and economic burden. The incidence of …

Osteoarthritis (OA) is a degenerative joint disease in the elderly. Although OA has been
considered as primarily a disease of the articular cartilage, the participation of subchondral …

In the mammalian skeletal system, osteogenesis and angiogenesis are intimately linked
during bone growth and regeneration in bone modeling and during bone homeostasis in …

Blood vessels form a versatile transport network that is best known for its critical roles in
processes such as tissue oxygenation, metabolism and immune surveillance. The …

Skeletal elements have a diverse range of shapes and sizes specialized to their various
roles including protecting internal organs, locomotion, feeding, hearing, and vocalization …

Bone vasculature and bone marrow vascular niches supply oxygen, nutrients, and secrete
angiocrine factors required for the survival, maintenance, and self‐renewal of stem and …

Synthetic glucocorticoids (GCs), one of the most effective treatments for chronic inflammatory
and autoimmune conditions in children, have adverse effects on the growing skeleton. GCs …

Receptor activator of NF‐κB ligand (RANKL) is essential for osteoclast formation and bone
remodeling. Nevertheless, the cellular source of RANKL for osteoclastogenesis has not …

Osteoclasts are multinucleated cells of the monocyte/macrophage lineage that degrade
bone. Here, we used lineage tracing studies—labelling cells expressing Cx3cr1, Csf1r or …