Globally, cardiovascular disease remains the leading cause of death. Most concerning is the
rise in cardiovascular risk factors including obesity, diabetes and hypertension among youth …

Pregnancy involves a range of metabolic adaptations to supply adequate energy for fetal
growth and development. Gestational diabetes (GDM) is defined as hyperglycemia with first …

Chronic diseases represent one of the major causes of death worldwide. It has been
suggested that pregnancy-related conditions, such as gestational diabetes mellitus (GDM) …

The results of different human epidemiological datasets provided the impetus to introduce
the now commonly accepted theory coined as 'developmental programming', whereby the …

Diabetes-related pathophysiological alterations and various female reproductive difficulties
were common in pregnant women with gestational diabetes mellitus (GDM), who had 21.1 …

Abstract Background Extrachromosomal circular DNA (eccDNA) has emerged as a
promising biomarker for disease diagnosis and prognosis prediction. However, its role in …

BACKGROUND: Despite prevention efforts, type 2 diabetes mellitus continues to increase in
incidence among First Nations children and is associated with early and aggressive …

The functional maturation of insulin-secreting β-cells is initiated before birth and is
completed in early postnatal life. This process has a critical impact on the acquisition of an …

Insulin resistance is a common feature of many metabolic disorders. The dramatic rise in the
incidence of insulin resistance over the past decade has enhanced focus on its …

Aims To evaluate the morphological changes in the pancreatic islet cells of adult female
pups born to diabetic rats and fed a high-fat diet. Main methods Female Sprague-Dawley …