Dipeptidyl‐peptidases: Key enzymes producing entry forms of extracellular proteins in asaccharolytic periodontopathic bacterium Porphyromonas gingivalis

TK Nemoto, Y Ohara Nemoto - Molecular oral microbiology, 2021 - Wiley Online Library
Porphyromonas gingivalis, a pathogen of chronic periodontitis, is an asaccharolytic
microorganism that solely utilizes nutritional amino acids as its energy source and cellular …

Computational modeling of molecular structures guided by hydrogen-exchange data

D Devaurs, DA Antunes, AJ Borysik - Journal of the American …, 2022 - ACS Publications
Data produced by hydrogen-exchange monitoring experiments have been used in structural
studies of molecules for several decades. Despite uncertainties about the structural …

New zinc ion parameters suitable for classical MD simulations of zinc metallopeptidases

A Tomic, G Horvat, M Ramek, D Agic… - Journal of chemical …, 2019 - ACS Publications
The main aim of this work was to find parameters for the zinc ion in human dipeptidyl
peptidase III (DPP III) active site that would enable its reliable modeling. Since the …

Metabolic cooperativity between Porphyromonas gingivalis and Treponema denticola

LX Kin, CA Butler, N Slakeski, B Hoffmann… - Journal of Oral …, 2020 - Taylor & Francis
ABSTRACT Background Porphyromonas gingivalis and Treponema denticola are
proteolytic periodontopathogens that co-localize in polymicrobial subgingival plaque …

Binding of dipeptidyl peptidase III to the oxidative stress cell sensor Kelch-like ECH-associated protein 1 is a two-step process

S Matić, I Kekez, M Tomin, F Bogár… - Journal of …, 2021 - Taylor & Francis
This work is about synergy of theory and experiment in revealing mechanism of binding of
dipeptidyl peptidase III (DPP III) and Kelch-like ECH-associated protein 1 (KEAP1), the main …

Structural and Functional Characterization of a New Bacterial Dipeptidyl Peptidase III Involved in Fruiting Body Formation in Myxobacteria

SB Chen, H Zhang, S Chen, XF Ye, ZK Li… - International Journal of …, 2022 - mdpi.com
Dipeptidyl peptidase III (DPP III) is a zinc-dependent enzyme that specifically hydrolyzes
dipeptides from the N-terminal of different-length peptides, and it is involved in a number of …

Neuropeptides, substrates and inhibitors of human dipeptidyl peptidase III, experimental and computational study—A new substrate identified

Z Karačić, F Šupljika, A Tomić, L Brkljačić… - International journal of …, 2022 - Elsevier
Abstract Dipeptidyl peptidase III (DPP III) is a cytosolic, two-domain zinc-exopeptidase. It is
widely distributed in mammalian tissues, where it's involved in the final steps of normal …

Conservation of the conformational dynamics and ligand binding within M49 enzyme family

S Kazazić, Z Karačić, I Sabljić, D Agić, M Tomin… - RSC …, 2018 - pubs.rsc.org
The hydrogen deuterium exchange (HDX) mass spectrometry combined with molecular
dynamics (MD) simulations was employed to investigate conformational dynamics and …

[PDF][PDF] The virulence system of Porphyromonas gingivalis: Genes, mechanism and potential role of gingipains inhibitors.

MA Sa'ad, R Kavitha, NK Fuloria, S Fuloria… - Malaysian Journal of …, 2021 - researchgate.net
The oral microbiome comprises several hundreds of bacterial species that contribute to
periodontitis, the most complex polymicrobial inflammatory disorder. Porphyromonas …

Comparaison des effets des vasopresseurs et immunothérapie du sepsis sur la croissance bactérienne: intérêt d'une alternative thérapeutique

PV Ayar - 2021 - theses.hal.science
Introduction: Le sepsis est une défaillance d'organe avec un risque vital induit par une
réponse inappropriée de l'hôte vis-à-vis d'une infection. La prise en charge symptomatique …