Functional role of the C-terminal amphipathic helix 8 of olfactory receptors and other G protein-coupled receptors

T Sato, T Kawasaki, S Mine, H Matsumura - International journal of …, 2016 - mdpi.com
G protein-coupled receptors (GPCRs) transduce various extracellular signals, such as
neurotransmitters, hormones, light, and odorous chemicals, into intracellular signals via G …

The anterior piriform cortex and predator odor responses: modulation by inhibitory circuits

M Matsukawa, M Yoshikawa, N Katsuyama… - Frontiers in Behavioral …, 2022 - frontiersin.org
Rodents acquire more information from the sense of smell than humans because they have
a nearly fourfold greater variety of olfactory receptors. They use olfactory information not only …

Distinctive classes of GABAergic interneurons provide layer-specific phasic inhibition in the anterior piriform cortex

N Suzuki, JM Bekkers - Cerebral cortex, 2010 - academic.oup.com
The primary olfactory (or piriform) cortex is a trilaminar paleocortex that is seen increasingly
as an attractive model system for the study of cortical sensory processing. Recent findings …

Sniffer mice discriminate urine odours of patients with bladder cancer: A proof-of-principle study for non-invasive diagnosis of cancer-induced odours

T Sato, Y Katsuoka, K Yoneda, M Nonomura… - Scientific reports, 2017 - nature.com
Similar to fingerprints, humans have unique, genetically determined body odours. In case of
urine, the odour can change due to variations in diet as well as upon infection or tumour …

Rose odor can innately counteract predator odor

M Matsukawa, M Imada, T Murakami, S Aizawa, T Sato - Brain research, 2011 - Elsevier
When animals smell a predator odor such as 2, 5-Dihydro-2, 4, 5-trimethylthiazoline (TMT),
even if it is a novel substance, the hypothalamo–pituitary–adrenal (HPA) axis is activated …

Supersensitive detection and discrimination of enantiomers by dorsal olfactory receptors: evidence for hierarchical odour coding

T Sato, R Kobayakawa, K Kobayakawa, M Emura… - Scientific Reports, 2015 - nature.com
Enantiomeric pairs of mirror-image molecular structures are difficult to resolve by
instrumental analyses. The human olfactory system, however, discriminates (−)-wine lactone …

Independent epileptiform discharge patterns in the olfactory and limbic areas of the in vitro isolated Guinea pig brain during 4-aminopyridine treatment

G Carriero, L Uva, V Gnatkovsky… - Journal of …, 2010 - journals.physiology.org
In vitro studies performed on brain slices demonstrate that the potassium channel blocker 4-
aminopyridine (4AP, 50 μM) discloses electrographic seizure activity and interictal …

Odor-and state-dependent olfactory tubercle local field potential dynamics in awake rats

KS Carlson, MR Dillione… - Journal of …, 2014 - journals.physiology.org
The olfactory tubercle (OT), a trilaminar structure located in the basal forebrain of mammals,
is thought to play an important role in olfaction. While evidence has accumulated regarding …

Stress-related activities induced by predator odor may become indistinguishable by hinokitiol odor

T Murakami, M Matsukawa, N Katsuyama, M Imada… - …, 2012 - journals.lww.com
Abstract Predator odors, such as 2, 5-dihydro-2, 4, 5-trimethylthiazoline (TMT), induce a
stress-like behavior in some rodents, and there is activation of a complex mix of brain …

Architecture of odor information processing in the olfactory system

T Sato, J Hirono, H Hamana, T Ishikawa… - Anatomical science …, 2008 - Springer
Since the discovery of the superfamily of approximately 1000 odorant receptor genes in
rodents, the structural simplicity as well as the complexity of the olfactory system have been …