Post-myocardial infarction fibrosis: Pathophysiology, examination, and intervention

X Yin, X Yin, X Pan, J Zhang, X Fan, J Li… - Frontiers in …, 2023 - frontiersin.org
Cardiac fibrosis plays an indispensable role in cardiac tissue homeostasis and repair after
myocardial infarction (MI). The cardiac fibroblast-to-myofibroblast differentiation and …

Application of Nanomaterials in Stem Cell‐Based Therapeutics for Cardiac Repair and Regeneration

J Qiu, XJ Liu, BA You, N Ren, H Liu - Small, 2023 - Wiley Online Library
Cardiovascular disease is a leading cause of disability and death worldwide. Although the
survival rate of patients with heart diseases can be improved with contemporary …

[HTML][HTML] Wireless electrical stimulation at the nanoscale interface induces tumor vascular normalization

C Li, C Xiao, L Zhan, Z Zhang, J Xing, J Zhai, Z Zhou… - Bioactive Materials, 2022 - Elsevier
Pathological angiogenesis frequently occurs in tumor tissue, limiting the efficiency of
chemotherapeutic drug delivery and accelerating tumor progression. However, traditional …

Reconstituted extracellular vesicles from human platelets decrease viral myocarditis in mice

DJ Beetler, KA Bruno, MM Watkins, V Xu, I Chekuri… - Small, 2023 - Wiley Online Library
Patients with viral myocarditis are at risk of sudden death and may progress to dilated
cardiomyopathy (DCM). Currently, no disease‐specific therapies exist to treat viral …

Insights into bone morphogenetic proteins in cardiovascular diseases

D Ye, Y Liu, H Pan, Y Feng, X Lu, L Gan… - Frontiers in …, 2023 - frontiersin.org
Bone morphogenetic proteins (BMPs) are secretory proteins belonging to the transforming
growth factor-β (TGF-β) superfamily. These proteins play important roles in embryogenesis …

MicroRNA roles in cell reprogramming mechanisms

E Pascale, C Caiazza, M Paladino, S Parisi, F Passaro… - Cells, 2022 - mdpi.com
Cell reprogramming is a groundbreaking technology that, in few decades, generated a new
paradigm in biomedical science. To date we can use cell reprogramming to potentially …

Polycomb group protein CBX7 represses cardiomyocyte proliferation through modulation of the TARDBP/RBM38 axis

KW Cho, M Andrade, S Bae, S Kim, J Eyun Kim… - Circulation, 2023 - Am Heart Assoc
Background: Shortly after birth, cardiomyocytes exit the cell cycle and cease proliferation. At
present, the regulatory mechanisms for this loss of proliferative capacity are poorly …

Designing biofunctional hydrogels for stem cell biology and regenerative medicine applications

TTH Thi, M Laney, H Zhang, F Martinez, Y Lee… - Journal of Industrial and …, 2024 - Elsevier
Stem cell therapy has shown remarkable promise for treating various diseases and
disorders. This strategy attenuates disease symptoms and stimulates endogenous and …

High‐Precision Single‐Cell microRNA Therapy by a Functional Nanopipette with Sensitive Photoelectrochemical Feedback

YW Zheng, SY Yu, Z Li, YT Xu, WW Zhao, D Jiang… - Small, 2024 - Wiley Online Library
This work proposes the concept of single‐cell microRNA (miR) therapy and proof‐of‐
concept by engineering a nanopipette for high‐precision miR‐21‐targeted therapy in a …

Direct conversion of cardiac fibroblasts into endothelial-like cells using Sox17 and Erg

G Farber, Y Dong, Q Wang, M Rathod, H Wang… - Nature …, 2024 - nature.com
Endothelial cells are a heterogeneous population with various organ-specific and conserved
functions that are critical to organ development, function, and regeneration. Here we report a …