Combinational therapies provoking cell death are of major interest in oncology. Combining
TORC2 kinase inhibition with the radiomimetic drug Zeocin results in a rapid accumulation …

Loss of cytosolic actin filaments upon TORC2 inhibition triggers chromosome fragmentation
in yeast, which results from altered base excision repair of Zeocin-induced lesions. To find …

The actin cytoskeleton is of fundamental importance for numerous cellular processes,
including intracellular transport, cell plasticity, and cell migration. However, functions of …

G0-G1 phase alternative end joining (A-EJ) is a recently defined mutagenic pathway
characterized by resected deletion and translocation joints that are predominantly direct and …

Nuclear deformability plays a critical role in cell migration. During this process, the
remodeling of internal components of the nucleus has a direct impact on DNA damage and …

DNA damage response (DDR) pathways play a crucial role in lung cancer. In this
retrospective analysis, we aimed to develop a prognostic model and molecular subtype …

The modern fluorescence microscope is the convergence point of technologies with different
performances in terms of statistical sampling, number of simultaneously analyzed signals …

Methamphetamine (METH) is shown to cause massive oxidative stress and apoptosis in
testicular tissue. This study attempted to investigate the possible effects of METH chronic …

Lung cancer cells in the tumor microenvironment facilitate immune evasion that leads to
failure of conventional chemotherapies, despite provisionally decided on the genetic …

Plant protoplasts are generated by treatment with digestion enzymes, producing plant cells
devoid of the cell wall and competent for efficient polyethylene glycol mediated …