New roles for GAPDH, Hsp90, and NO in regulating heme allocation and hemeprotein function in mammals

DJ Stuehr, Y Dai, P Biswas, EA Sweeny… - Biological …, 2022 - degruyter.com
The intracellular trafficking of mitochondrial heme presents a fundamental challenge to
animal cells. This article provides some background on heme allocation, discusses some of …

Photoferrotrophs produce a PioAB electron conduit for extracellular electron uptake

D Gupta, MC Sutherland, K Rengasamy, JM Meacham… - MBio, 2019 - Am Soc Microbiol
Photoferrotrophy is a form of anoxygenic photosynthesis whereby bacteria utilize soluble or
insoluble forms of ferrous iron as an electron donor to fix carbon dioxide using light energy …

Iron oxidation by a fused cytochrome-porin common to diverse iron-oxidizing bacteria

JL Keffer, SM McAllister, AI Garber, BJ Hallahan… - MBio, 2021 - Am Soc Microbiol
Iron (Fe) oxidation is one of Earth's major biogeochemical processes, key to weathering, soil
formation, water quality, and corrosion. However, our understanding of microbial …

In vitro reconstitution reveals major differences between human and bacterial cytochrome c synthases

MC Sutherland, DL Mendez, SE Babbitt, DE Tillman… - Elife, 2021 - elifesciences.org
Cytochromes c are ubiquitous heme proteins in mitochondria and bacteria, all possessing a
CXXCH (CysXxxXxxCysHis) motif with covalently attached heme. We describe the first in …

Structure-function analysis of the heme-binding WWD domain in the bacterial holocytochrome c synthase, CcmFH

AL Grunow, SC Carroll, AN Kreiman, MC Sutherland - Mbio, 2023 - Am Soc Microbiol
Heme trafficking is a fundamental biological process, yet its direct study has been hampered
due to heme's tight intracellular regulation, heme cytotoxicity, and the transient nature of …

Structure-Function Analysis of the Bifunctional CcsBA Heme Exporter and Cytochrome c Synthetase

MC Sutherland, NL Tran, DE Tillman, JM Jarodsky… - MBio, 2018 - Am Soc Microbiol
Although intracellular heme trafficking must occur for heme protein assembly, only a few
heme transporters have been unequivocally discovered and nothing is known about their …

Structurally mapping endogenous heme in the CcmCDE membrane complex for cytochrome c biogenesis

MC Sutherland, JM Jarodsky, S Ovchinnikov… - Journal of molecular …, 2018 - Elsevier
Although many putative heme transporters have been discovered, it has been challenging to
prove that these proteins are directly involved with heme trafficking in vivo and to identify …

Cytochrome bc1 Complex: Potential Breach to Improve the Activity of Phenazines on Xanthomonas

J Wu, Q Teng, Y Mao, Y Duan, X Pan… - Journal of Agricultural …, 2022 - ACS Publications
The effects of the natural pesticides, phenazines, were reported to be limited by some
tolerant metabolism processes within Xanthomonas. Our previous studies suggested that …

The CcmC–CcmE interaction during cytochrome c maturation by System I is driven by protein–protein and not protein–heme contacts

SH Shevket, D Gonzalez, JL Cartwright… - Journal of Biological …, 2018 - ASBMB
Cytochromes c are ubiquitous proteins, essential for life in most organisms. Their distinctive
characteristic is the covalent attachment of heme to their polypeptide chain. This post …

[PDF][PDF] Photoferrotrophs produce a PioAB electron conduit for extracellular electron uptake. mBio 10: e02668-19

D Gupta, MC Sutherland, K Rengasamy, JM Meacham… - 2019 - academia.edu
Photoferrotrophy is a form of anoxygenic photosynthesis whereby bacteria utilize soluble or
insoluble forms of ferrous iron as an electron donor to fix carbon dioxide using light energy …