Importance Non–small cell lung cancer remains the leading cause of cancer death in the
United States. Until the last decade, the 5-year overall survival rate for patients with …

Lung cancer continues to be the leading cause of cancer-related death worldwide. In the last
decade, significant advancements in the diagnosis and treatment of lung cancer, particularly …

The potential of the cluster regularly interspaced short palindromic repeat (CRISPR)‐
associated protein 9 (Cas9)‐based therapeutic genome editing is severely hampered by the …

Germline aberrations in critical DNA-repair and DNA damage–response (DDR) genes
cause cancer predisposition, whereas various tumors harbor somatic mutations causing …

Background Chromosomal rearrangements of the gene encoding ROS1 proto-oncogene
receptor tyrosine kinase (ROS1) define a distinct molecular subgroup of non–small-cell lung …

Genome instability is a hallmark of cancer, and DNA replication is the most vulnerable
cellular process that can lead to it. Any condition leading to high levels of DNA damage will …

Immunogenic cell death (ICD) converts dying cancer cells into a therapeutic vaccine and
stimulates antitumor immune responses. Here we unravel the results of an unbiased screen …

Type 1 diabetes is characterized by the destruction of pancreatic β cells, and generating
new insulin-producing cells from other cell types is a major aim of regenerative medicine …

Thermal proteome profiling (TPP) is based on the principle that, when subjected to heat,
proteins denature and become insoluble. Proteins can change their thermal stability upon …

Purpose The ROS1 tyrosine kinase is activated through ROS1 gene rearrangements in 1%
to 2% of non–small-cell lung cancers (NSCLCs), which confer sensitivity to treatment with …