Protein–protein interfaces play fundamental roles in the molecular mechanisms underlying
pathophysiological pathways and are important targets for the design of compounds of …

Kallikrein-related peptidases (KLKs) are a family of serine proteases that when dysregulated
may contribute to neuroinflammation and neurodegeneration. In the present review article …

The tumor-suppressor gene tumor protein p53 (TP53) is one of the most commonly mutated
genes in human lung cancer, and TP53 mutations are associated with a worsened …

Neuroendocrine prostate carcinoma (NEPC) accounts for less than 1% of prostate
neoplasms and has extremely poorer prognosis than the typical androgen receptor pathway …

Introduction: Aberrant levels of kallikrein-related peptidases (KLK1-15) have been linked to
cancer cell proliferation, invasion and metastasis. In ovarian cancer, the KLK proteolytic …

Background Renal cell carcinoma (RCC) is associated with poor prognostic outcomes. The
current stratifying system does not predict prognostic outcomes and therapeutic benefits …

Abstract Background Kallikrein 6 (KLK6) is known to be an age-related protease expressed
at high levels in the central nervous system. It was previously shown to be involved in …

Alzheimer's disease (AD) and related dementias constitute an important global health
challenge. Detailed understanding of the multiple molecular mechanisms underlying their …

Intraductal carcinoma of the prostate (IDCP) has recently attracted increasing interest owing
to its unfavorable prognoses. To effectively identify the IDCP-specific gene expression …

Identification of the signature molecular profiles involved in therapy resistance is of vital
importance in developing new strategies for treatments and disease monitoring. Protein …