The medicinal chemistry of ferrocene and its derivatives
Ferrocene derivatives have attracted significant interest as anticancer, antibacterial,
antifungal and antiparasitic drug candidates. Discovered in the 1990s, the two most …
antifungal and antiparasitic drug candidates. Discovered in the 1990s, the two most …
Praziquantel for schistosomiasis: single-drug metabolism revisited, mode of action, and resistance
Schistosomiasis, a major neglected tropical disease, affects more than 250 million people
worldwide. Treatment of schistosomiasis has relied on the anthelmintic drug praziquantel …
worldwide. Treatment of schistosomiasis has relied on the anthelmintic drug praziquantel …
Synthesis, structural characterization, DFT calculations, molecular docking, and molecular dynamics simulations of a novel ferrocene derivative to unravel its potential …
MM Hammoud, M Khattab, M Abdel-Motaal… - Journal of …, 2023 - Taylor & Francis
In this article, we describe a set of subsequent five-steps chemical reactions to synthesize a
ferrocene derivative named 1-(5-(diphenylphosphaneyl) cyclopenta-1, 3-dien-1-yl) ethyl) …
ferrocene derivative named 1-(5-(diphenylphosphaneyl) cyclopenta-1, 3-dien-1-yl) ethyl) …
Metal compounds against neglected tropical diseases
Many first-line treatments for neglected tropical diseases identified by the World Health
Organization (WHO) are limited by one or more of the following: the development of drug …
Organization (WHO) are limited by one or more of the following: the development of drug …
Molecular and cellular characterization of the biological effects of ruthenium (II) complexes incorporating 2-pyridyl-2-pyrimidine-4-carboxylic acid
V Pierroz, T Joshi, A Leonidova, C Mari… - Journal of the …, 2012 - ACS Publications
A great majority of the Ru complexes currently studied in anticancer research exert their
antiproliferative activity, at least partially, through ligand exchange. In recent years, however …
antiproliferative activity, at least partially, through ligand exchange. In recent years, however …
Targeting nucleus DNA with a cyclometalated dipyridophenazineruthenium (II) complex
Recently, coordinatively saturated and substitutionally inert Ru (II) complexes have been
investigated as anticancer agents. Herein a cyclometalated Ru (II) complex,[Ru …
investigated as anticancer agents. Herein a cyclometalated Ru (II) complex,[Ru …
Enhancing the activity of drugs by conjugation to organometallic fragments
P Chellan, PJ Sadler - Chemistry–A European Journal, 2020 - Wiley Online Library
Resistance to chemotherapy is a current clinical problem, especially in the treatment of
microbial infections and cancer. One strategy to overcome this is to make new derivatives of …
microbial infections and cancer. One strategy to overcome this is to make new derivatives of …
Ferrocene derivatives as anti-infective agents
BS Ludwig, JDG Correia, FE Kühn - Coordination Chemistry Reviews, 2019 - Elsevier
Infectious diseases like malaria, tuberculosis or HIV are among the leading causes of death
worldwide according to WHO estimations. Nevertheless, the fight against infectious diseases …
worldwide according to WHO estimations. Nevertheless, the fight against infectious diseases …
Synthesis, characterization, and biological evaluation of new Ru (II) polypyridyl photosensitizers for photodynamic therapy
Two Ru (II) polypyridyl complexes, Ru (DIP) 2 (bdt)(1) and [Ru (dqpCO2Me)(ptpy)]
2+(2)(DIP= 4, 7-diphenyl-1, 10-phenanthroline, bdt= 1, 2-benzenedithiolate, dqpCO2Me= 4 …
2+(2)(DIP= 4, 7-diphenyl-1, 10-phenanthroline, bdt= 1, 2-benzenedithiolate, dqpCO2Me= 4 …
Towards cancer cell-specific phototoxic organometallic rhenium (I) complexes
A Leonidova, V Pierroz, R Rubbiani, J Heier… - Dalton …, 2014 - pubs.rsc.org
Over the recent years, several Re (I) organometallic compounds have been shown to be
toxic to various cancer cell lines. However, these compounds lacked sufficient selectivity …
toxic to various cancer cell lines. However, these compounds lacked sufficient selectivity …