Genetic mosaicism is the result of the accumulation of somatic mutations in the human
genome starting from the first postzygotic cell generation and continuing throughout the …

The neocortex is the seat of higher cognitive functions and, in evolutionary terms, is the
youngest part of the mammalian brain. Since its origin, the neocortex has expanded in …

Radial glia, the neural stem cells of the neocortex, are located in two niches: the ventricular
zone and outer subventricular zone. Although outer subventricular zone radial glia may …

INTRODUCTION What determines the pace of embryonic development? Although the
molecular and cellular mechanisms of many developmental processes are evolutionarily …

Our understanding of the genetics of the human cerebral cortex is limited both in terms of the
diversity and the anatomical granularity of brain structural phenotypes. Here we conducted a …

Neural stem and progenitor cells have a central role in the development and evolution of the
mammalian neocortex. In this review, we first provide a set of criteria to classify the various …

Variation in cerebral cortex size and complexity is thought to contribute to differences in
cognitive ability between humans and other animals. Here we compare cortical progenitor …

Resolving lineage relationships between cells in an organism is a fundamental interest of
developmental biology. Furthermore, investigating lineage can drive understanding of …

Since descriptions of neural precursor cells (NPCs) were published in the late 19th century,
neuroanatomists have used a variety of terms to describe these cells, each term reflecting …

The diverse progenitors that give rise to the human neocortex have been difficult to
characterize because progenitors, particularly radial glia (RG), are rare and are defined by a …