Chemical reprogramming offers an unprecedented opportunity to control somatic cell fate
and generate desired cell types including pluripotent stem cells for applications in …

Though totipotency and pluripotency are transient during early embryogenesis, they
establish the foundation for the development of all mammals. Studying these in vivo has …

A hallmark of eukaryotic aging is a loss of epigenetic information, a process that can be
reversed. We have previously shown that the ectopic induction of the Yamanaka factors …

A formal demonstration that mammalian pluripotent stem cells possess preimplantation
embryonic cell-like (naive) pluripotency is the generation of chimeric animals through early …

Rapid development of high-throughput single-cell RNA sequencing (scRNA-seq)
technologies offers exciting opportunities to reveal new and rare cell types, previously …

Synthetic embryology aims to develop embryo-like structures from stem cells to provide new
insight into early stages of mammalian development. Recent advances in synthetic …

Developing functional organs from stem cells remains a challenging goal in regenerative
medicine. Existing methodologies, such as tissue engineering, bioprinting, and organoids …

Early embryo development is a highly dynamic process that plays a crucial role in
determining the health and characteristics of an organism. For many years, embryonic and …

Stem cells offer new therapeutic avenues for the repair and replacement of damaged tissues
and organs owing to their self-renewal and multipotent differentiation capabilities. In this …

Cellular totipotency is critical for whole-organism generation, yet how totipotency is
established remains poorly illustrated. Abundant transposable elements (TEs) are activated …