Abstract Carbonic anhydrase (CA, EC 4.2. 1.1) is an enzyme and a very omnipresent zinc
metalloenzyme which catalyzed the reversible hydration and dehydration of carbon dioxide …

In recent decades, the development of targeted drugs has featured prominently in the
treatment of cancer, which is among the major causes of mortality globally. Triazole-fused …

New efficient antimicrobial agents are urgently needed to combat invasive multidrug-
resistant pathogens infections. Structurally unique benzenesulfonyl thiazoloimines (BSTIs) …

A unique class of antibacterial azolylpyrimidinediols (APDs) and their analogues were
developed. Some synthesized compounds showed excellent bacteriostatic potency; …

Presently, dual targeting by a single small molecule stands out as an effective cancer-
fighting weapon. Carbonic anhydrase (CA) and vascular-endothelial growth factor (VEGF) …

The “tail approach” has become a milestone in human carbonic anhydrase inhibitor (hCAI)
design for various therapeutics, including antiglaucoma agents. Besides the classical …

The hydrophobic and the hydrophilic rims in the active site of human carbonic anhydrase IX
(hCA IX) which as well contains a zinc ion as part of the catalytic core, were simultaneously …

In this work, new isatin-based sulphonamides (6a-i, 11a-c, 12a-c) were designed and
synthesised as potential dual VEGFR-2 and carbonic anhydrase inhibitors with anticancer …

Main observation and conclusion The limit ability of traditional antibiotics to treat drug
resistant bacteria calls for new therapeutic alternatives. A class of unique sulfanilamide …

A series of 2-aminothiazole sulfanilamide oximes were developed as new membrane active
antibacterial agents to conquer the microbial infection. Benzoyl derivative 10c was …