The current status of cell‐free human papillomavirus DNA as a biomarker in cervical cancer and other HPV‐associated tumors: A review

L Sivars, K Palsdottir… - … Journal of Cancer, 2023 - Wiley Online Library
Tumor cells release fragments of their DNA into the circulation, so called cell‐free tumor
DNA (ctDNA), allowing for analysis of tumor DNA in a simple blood test, that is, liquid biopsy …

Cell-free DNA: a promising biomarker in infectious diseases

Y Hu, Y Zhao, Y Zhang, W Chen, H Zhang, X Jin - Trends in Microbiology, 2024 - cell.com
Infectious diseases pose serious threats to public health worldwide. Conventional diagnostic
methods for infectious diseases often exhibit low sensitivity, invasiveness, and long …

HPV sequencing facilitates ultrasensitive detection of HPV circulating tumor DNA

E Leung, K Han, J Zou, Z Zhao, Y Zheng, TT Wang… - Clinical Cancer …, 2021 - AACR
Abstract Purpose: Human papillomavirus (HPV) DNA offers a convenient circulating tumor
DNA (ctDNA) marker for HPV-associated malignancies, but current methods, such as digital …

A novel photoelectrochemical array platform for ultrasensitive multiplex detection and subtype identification of HPV genes

Y Sun, J Liu, X Peng, G Zhang, Y Li - Biosensors and Bioelectronics, 2023 - Elsevier
The rapid, low-cost and user-friendly methods for nucleic acid detection is urgently needed.
Here we developed a miniaturized and convenient photoelectrochemical biosensor array …

Blood and saliva‐derived ctDNA is a marker of residual disease after treatment and correlates with recurrence in human papillomavirus‐associated head and neck …

ST Ferrier, T Tsering, N Sadeghi, A Zeitouni… - Cancer …, 2023 - Wiley Online Library
Background There is an alarming increase in human papillomavirus‐associated head and
neck cancer (HNC), reaching epidemic levels. While patient prognosis is generally good, off …

Clinical applications and utility of cell-free DNA-based liquid biopsy analyses in cervical cancer and its precursor lesions

J Herbst, K Pantel, K Effenberger, H Wikman - British Journal of Cancer, 2022 - nature.com
Human papilloma virus (HPV) is an infectious carcinogenic agent. Nearly all cervical
cancers are positive for one of the high-risk HPV subtypes. Although the introduction of the …

Comparing the Diagnostic Performance of Quantitative PCR, Digital Droplet PCR, and Next-Generation Sequencing Liquid Biopsies for Human Papillomavirus …

S Naegele, DA Ruiz-Torres, Y Zhao, D Goss… - The Journal of Molecular …, 2024 - Elsevier
Human papillomavirus (HPV)-associated cancers, including oropharyngeal squamous cell
carcinoma (HPV+ OPSCC), cervical cancer, and squamous cell carcinoma of the anus …

Detection of circulating HPV16 DNA as a biomarker for cervical cancer by a bead-based HPV genotyping assay

L Galati, JD Combes, F Le Calvez-Kelm… - Microbiology …, 2022 - Am Soc Microbiol
Human papillomavirus (HPV) circulating tumor DNA (HPV ctDNA) was proposed as a
biomarker for the detection and disease monitoring of HPV-related cancers. One hundred …

Circulating HPV DNA in HPV-associated cancers

G Lin, J Li - Clinica Chimica Acta, 2023 - Elsevier
Human papillomavirus (HPV) infections are the primary cause of almost all cervical cancers,
anal cancers, and a variable proportion of other anogenital tumors, as well as head and …

Circulating cell‐free HPV DNA is a strong marker for disease severity in cervical cancer

S Bønløkke, T Steiniche, BS Sorensen… - Molecular …, 2024 - Wiley Online Library
For cervical cancer (CC), circulating cell‐free HPV DNA (ccfHPV) may establish disease
severity. Furthermore, HPV integration has been correlated to viral load and survival. In this …