A comprehensive review of monoamine oxidase inhibitors as Anti-Alzheimer's disease agents: A review
Monoamine oxidases (MAO-A and MAO-B) are mammalian flavoenzyme, which catalyze the
oxidative deamination of several neurotransmitters like norepinephrine, dopamine, tyramine …
oxidative deamination of several neurotransmitters like norepinephrine, dopamine, tyramine …
Pyrazoline containing compounds as therapeutic targets for neurodegenerative disorders
Pyrazolines are a significant class of heterocyclic compounds with essential biological
activities. They are quite stable, which has inspired medicinal chemists to experiment with …
activities. They are quite stable, which has inspired medicinal chemists to experiment with …
The Synthesis of Schiff bases and new secondary amine derivatives of p-vanillin and evaluation of their neuroprotective, antidiabetic, antidepressant and antioxidant …
N Yuldasheva, N Acikyildiz, M Akyuz… - Journal of Molecular …, 2022 - Elsevier
In the current study, five Schiff base derivatives coded as VDOPL (1), VHISL (2), V2-AFL (3),
V4-AFL (4) and VAML (5) from p-vanillin were synthesized with dopamine, histamine, 2 …
V4-AFL (4) and VAML (5) from p-vanillin were synthesized with dopamine, histamine, 2 …
Design and synthesis of novel quinazolinone–chalcone hybrids as potential apoptotic candidates targeting caspase-3 and PARP-1: in vitro, molecular docking, and …
EA Madbouly, ESM Lashine, AA Al-Karmalawy… - New Journal of …, 2022 - pubs.rsc.org
A new series of thirty-one quinazolinone–chalcone hybrid molecules 13–43 were designed,
synthesized, and structurally characterized by different spectroscopic techniques. All the …
synthesized, and structurally characterized by different spectroscopic techniques. All the …
MAO enzymes inhibitory activity of new benzimidazole derivatives including hydrazone and propargyl side chains
In the present work, 15 new N'-(arylidene)-4-(1-(prop-2-yn-1-yl)-1H-benzo [d] imidazol-2-yl)
benzohydrazide (4a-4o) were designed and synthesized. The structures of the synthesized …
benzohydrazide (4a-4o) were designed and synthesized. The structures of the synthesized …
Design, Synthesis, and In Vitro and In Silico Approaches of Novel Indanone Derivatives as Multifunctional Anti-Alzheimer Agents
Alzheimer's disease (AD) is a neurological, progressive illness that typically affects the
elderly and is clinically distinguished by memory and cognitive decline. Due to a number of …
elderly and is clinically distinguished by memory and cognitive decline. Due to a number of …
In vitro and in silico evaluation of new thiazole compounds as monoamine oxidase inhibitors
New twenty compounds bearing thiazole ring (3a-3t) were designed and synthesized as
monoamine oxidase (MAO) inhibitors. The fluorometric enzyme inhibition assay was used to …
monoamine oxidase (MAO) inhibitors. The fluorometric enzyme inhibition assay was used to …
Synthesis of new hydrazone derivatives and evaluation of their monoamine oxidase inhibitory activity
A novel series of hydrazone derivatives were designed and synthesized. Their structures
were characterized by IR, 1 H NMR, 13 C NMR and HR-MS spectroscopic methods. The …
were characterized by IR, 1 H NMR, 13 C NMR and HR-MS spectroscopic methods. The …
Development of fluorinated methoxylated chalcones as selective monoamine oxidase-B inhibitors: Synthesis, biochemistry and molecular docking studies
A series of methoxylated chalcones with fluoro and trifluoromethyl derivatives were
synthesized and investigated for their ability to inhibit human monoamine oxidase A and B …
synthesized and investigated for their ability to inhibit human monoamine oxidase A and B …
Study on the neuroprotective, radical-scavenging and MAO-B inhibiting properties of new benzimidazole arylhydrazones as potential multi-target drugs for the …
N Anastassova, D Aluani, N Hristova-Avakumova… - Antioxidants, 2022 - mdpi.com
Oxidative stress is a key contributing factor in the complex degenerating cascade in
Parkinson's disease. The inhibition of MAO-B affords higher dopamine bioavailability and …
Parkinson's disease. The inhibition of MAO-B affords higher dopamine bioavailability and …