Co-transcriptional gene regulation in eukaryotes and prokaryotes

M Shine, J Gordon, L Schärfen, D Zigackova… - … Reviews Molecular Cell …, 2024 - nature.com
Many steps of RNA processing occur during transcription by RNA polymerases. Co-
transcriptional activities are deemed commonplace in prokaryotes, in which the lack of …

Regulation of mRNA stability during bacterial stress responses

DA Vargas-Blanco, SS Shell - Frontiers in microbiology, 2020 - frontiersin.org
Bacteria have a remarkable ability to sense environmental changes, swiftly regulating their
transcriptional and posttranscriptional machinery as a response. Under conditions that …

Hepatitis C virus RNA is 5′-capped with flavin adenine dinucleotide

AV Sherwood, LR Rivera-Rangel, LA Ryberg… - Nature, 2023 - nature.com
RNA viruses have evolved elaborate strategies to protect their genomes, including 5′
capping. However, until now no RNA 5′ cap has been identified for hepatitis C virus,(HCV) …

Recent insights into noncanonical 5′ capping and decapping of RNA

SK Doamekpor, S Sharma, M Kiledjian… - Journal of Biological …, 2022 - ASBMB
The 5′ N 7-methylguanosine cap is a critical modification for mRNAs and many other RNAs
in eukaryotic cells. Recent studies have uncovered an RNA 5′ capping quality surveillance …

Highly efficient 5' capping of mitochondrial RNA with NAD+ and NADH by yeast and human mitochondrial RNA polymerase

JG Bird, U Basu, D Kuster, A Ramachandran… - Elife, 2018 - elifesciences.org
Bacterial and eukaryotic nuclear RNA polymerases (RNAPs) cap RNA with the oxidized and
reduced forms of the metabolic effector nicotinamide adenine dinucleotide, NAD+ and …

Toll/interleukin-1 receptor (TIR) domain-containing proteins have NAD-RNA decapping activity

X Wang, D Yu, J Yu, H Hu, R Hang, Z Amador… - Nature …, 2024 - nature.com
The occurrence of NAD+ as a non-canonical RNA cap has been demonstrated in diverse
organisms. TIR domain-containing proteins present in all kingdoms of life act in defense …

Identification, biosynthesis, and decapping of NAD-capped RNAs in B. subtilis

J Frindert, Y Zhang, G Nübel, M Kahloon, L Kolmar… - Cell Reports, 2018 - cell.com
The ubiquitous coenzyme nicotinamide adenine dinucleotide (NAD) decorates various
RNAs in different organisms. In the proteobacterium Escherichia coli, the NAD-cap confers …

NAD tagSeq reveals that NAD+-capped RNAs are mostly produced from a large number of protein-coding genes in Arabidopsis

H Zhang, H Zhong, S Zhang, X Shao… - Proceedings of the …, 2019 - National Acad Sciences
The 5′ end of a eukaryotic mRNA transcript generally has a 7-methylguanosine (m7G) cap
that protects mRNA from degradation and mediates almost all other aspects of gene …

ONE-seq: epitranscriptome and gene-specific profiling of NAD-capped RNA

K Niu, J Zhang, S Ge, D Li, K Sun, Y You… - Nucleic Acids …, 2023 - academic.oup.com
The hub metabolite, nicotinamide adenine dinucleotide (NAD), can be used as an initiating
nucleotide in RNA synthesis to result in NAD-capped RNAs (NAD-RNA). Since NAD has …

[HTML][HTML] The enigmatic epitranscriptome of bacteriophages: putative RNA modifications in viral infections

N Pozhydaieva, M Wolfram-Schauerte… - Current Opinion in …, 2024 - Elsevier
Highlights•RNA can be modified by diverse internal and terminal modifications.•Bacteria and
bacteriophage RNA polymerases can install RNA modifications.•Bacterial enzymes remove …