Insulin resistance is a major underlying mechanism for the “metabolic syndrome”, which is
also known as insulin resistance syndrome. Metabolic syndrome is increasing at an …

For many years, adipose tissue was considered as an inert energy storage organ that
accumulates and stores triacylglycerols during energy excess and releases fatty acids in …

The insulin receptor substrate proteins IRS1 and IRS2 are key targets of the insulin receptor
tyrosine kinase and are required for hormonal control of metabolism. Tissues from insulin …

Physiologically important cell-signalling networks are complex, and contain several points of
regulation, signal divergence and crosstalk with other signalling cascades. Here, we use the …

Recent studies using magnetic resonance spectroscopy have shown that decreased insulin-
stimulated muscle glycogen synthesis due to a defect in insulin-stimulated glucose transport …

Insulin signaling controls cell growth and metabolic homeostasis. Dysregulation of this
pathway causes metabolic diseases such as diabetes. Insulin signaling pathways have …

▪ Abstract The insulin resistance syndrome refers to a constellation of findings, including
glucose intolerance, obesity, dyslipidemia, and hypertension, that promote the development …

Deregulation of signaling pathways, through mutation or other molecular changes, can
ultimately result in disease. The tyrosine phosphatase Shp2 has emerged as a major …

Natural product berberine (BBR) has been reported to have hypoglycemic and insulin-
sensitizing activities; however, its mechanism remains unclear. This study was designed to …

Epigenetic inheritance is a potential mechanism by which the environment in one
generation can influence the performance of future generations. Rapid climate change …