Atorvastatin: a review of analytical methods for pharmaceutical quality control and monitoring

AC Kogawa, AEDT Pires… - Journal of AOAC …, 2019 - academic.oup.com
Background: Atorvastatin, a lipid-regulating drug, was the best-selling drug in the world in
the early 2000s. Thus, monitoring of this drug is important because it is accessible to a large …

Electroanalysis of Statin Drugs: A Review on the Electrochemical Sensor Architectures Ranging from Classical to Modern Systems

A Martins de Oliveira, R Matias Silva… - Critical Reviews in …, 2024 - Taylor & Francis
An overview of the latest advances in the design of electrochemical sensor architectures
dedicated to the determination of drugs from the statin class is presented in this review …

Structural, spectroscopic (NMR, IR, and Raman), and DFT investigation of the self-assembled nanostructure of pravastatin-LDH (layered double hydroxides) systems

VRR Cunha, PAD Petersen, MB Goncalves… - Chemistry of …, 2012 - ACS Publications
Layered double hydroxide (LDH) nanocontainers, suitable as carriers for anionic drugs,
were intercalated with Pravastatin drug using magnesium–aluminum and zinc–aluminum in …

Comparative study of topical green and red propolis in the repair of wounds induced in rats

LLV Batista, EA Campesatto, MLB Assis… - Revista do Colégio …, 2012 - SciELO Brasil
ABSTRACT Objective Objective: To evaluate the healing action of green and red propolis,
correlating it with the content of flavonoids. Methods: We performed quantification of total …

Significant progress in improving Atorvastatin dissolution rate: physicochemical characterization and stability assessment of self-dispersible Atorvastatin/Tween 80® …

A Rossetti, DA Real, BA Barrientos… - International Journal of …, 2024 - Elsevier
Atorvastatin (ATV) is a first-line drug for the treatment of hyperlipidemia. This drug presents
biopharmaceutical problems, partly due to its low solubility and dissolution rate. In this work …

Structural and biomechanical changes in the Achilles tendon after chronic treatment with statins

LP De Oliveira, CP Vieira, FD Guerra… - Food and Chemical …, 2015 - Elsevier
Cases of tendinopathy and tendon ruptures have been reported as side effects associated
with statin therapy. This work assessed possible changes in the structural and …

Preparation and characterization of solid dispersion of simvastatin

TD Silva, VT Arantes, JALC Resende… - Drug development …, 2010 - Taylor & Francis
Context: Simvastatin (SIM), a widely used drug for the treatment of hypercholesterolemia, is
a crystalline substance and practically insoluble in water. Its low dissolution rate leads to a …

Grape juice attenuates left ventricular hypertrophy in dyslipidemic mice

ÂM Martins, DAQ Silva Sarto, KP Caproni, J Silva… - Plos one, 2020 - journals.plos.org
Objective We evaluated the effects of grape juice (Vitis labrusca L.) on dyslipidemia,
resistance to insulin, and left ventricular hypertrophy (LVH) in mice homozygous for the …

In vivo and in vitro anti-inflammatory and anti-nociceptive activities of lovastatin in rodents

D Goncalves, IBF Calou, RP Siqueira… - Brazilian Journal of …, 2011 - SciELO Brasil
Statins are among the most prescribed drugs in recent clinical practice. They are also known
for their pleiotropic actions, which are independent of their lipid-lowering properties. The …

PAI-1 inhibition by simvastatin as a positive adjuvant in cell therapy

CA de Faria, DL Zanette, WA Silva… - Molecular biology …, 2019 - Springer
Cell therapy (CT) can be briefly described as the use of cells or cell components in the
treatment of diseases. One of the main challenges in establishing new cell types for therapy …