Rheumatoid factor and immune networks.
DA Carson, PP Chen, RI Fox, TJ Kipps… - Annual review of …, 1987 - europepmc.org
Rheumatoid factors represent a normal component of the immune network. The
autoantibodies promote complement fixation and clearance of immune complexes. They …
autoantibodies promote complement fixation and clearance of immune complexes. They …
Antibody multispecificity in immunoassay interference
SS Levinson - Clinical biochemistry, 1992 - Elsevier
Recent findings indicate that many endogenous antibodies exhibit multispecificity. These
antibodies exhibit a potential for interference with immunoassays. Antibodies that interfere …
antibodies exhibit a potential for interference with immunoassays. Antibodies that interfere …
Autoantibody-associated kappa light chain variable region gene expressed in chronic lymphocytic leukemia with little or no somatic mutation. Implications for etiology …
TJ Kipps, E Tomhave, PP Chen… - The Journal of …, 1988 - rupress.org
Recently the minor B cell subpopulation that expresses the CD5 (Leu-1) antigen has been
implicated as a source of IgM autoantibodies. Chronic lymphocytic leukemia (CLL), the most …
implicated as a source of IgM autoantibodies. Chronic lymphocytic leukemia (CLL), the most …
Mice that make VL binding proteins
L MacDonald, S Stevens, C Gurer, KA Hosiawa… - US Patent …, 2016 - Google Patents
Genetically modified mice and methods for making an using them are provided, wherein the
mice comprise a replacement of all or substantially all immunoglobulin heavy chain V gene …
mice comprise a replacement of all or substantially all immunoglobulin heavy chain V gene …
A conserved human germline V kappa gene directly encodes rheumatoid factor light chains.
V Radoux, PP Chen, JA Sorge… - The Journal of …, 1986 - europepmc.org
The full-length gene that encodes the light chain variable regions of an idiotypically related
group of human IgM kappa rheumatoid factors (RFs) has been cloned and sequenced. The …
group of human IgM kappa rheumatoid factors (RFs) has been cloned and sequenced. The …
Complete amino acid sequences of variable regions of two human IgM rheumatoid factors, BOR and KAS of the Wa idiotypic family, reveal restricted use of heavy and …
MM Newkirk, RA Mageed, R Jefferis, PP Chen… - The Journal of …, 1987 - rupress.org
Evidence derived from the complete amino acid sequences of the variable regions of both
the heavy and light chains of two members (BOR and KAS) of the Wa idiotypic family of …
the heavy and light chains of two members (BOR and KAS) of the Wa idiotypic family of …
A 16/6 idiotype—positive anti‐DNA antibody is encoded by a conserved VH gene with no somatic mutation
PP Chen, MF Liu, S Sinha… - Arthritis & Rheumatism …, 1988 - Wiley Online Library
Recently, the heavy chain of 16/6 idiotype—positive human anti‐DNA antibodies was found
to be similar, but not identical, to the VH26 gene. We resequenced the VH26 gene and …
to be similar, but not identical, to the VH26 gene. We resequenced the VH26 gene and …
Humanized light chain mice
L MacDonald, C Gurer, KA Meagher, S Stevens… - US Patent …, 2017 - Google Patents
2013-07-29 Assigned to REGENERON PHARMACEUTICALS, INC. reassignment
REGENERON PHARMACEUTICALS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE …
REGENERON PHARMACEUTICALS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE …
Idiotypic and subgroup analysis of human monoclonal rheumatoid factors. Implications for structural and genetic basis of autoantibodies in humans.
GJ Silverman, RD Goldfien, P Chen… - The Journal of …, 1988 - Am Soc Clin Investig
Rheumatoid factors (RFs) in humans have been studied intensively because of their
association with autoimmune and lymphoproliferative diseases. Many human IgM-RFs …
association with autoimmune and lymphoproliferative diseases. Many human IgM-RFs …
Rheumatoid factor
PP Chen, S Fong, DA Carson - Rheumatic Disease Clinics of North …, 1987 - Elsevier
Many human RF-associated crossreactive idiotypes (CRIs) have been defined. Since these
CRIs probably are the phenotypic markers of Ig variable region genes, the data suggest that …
CRIs probably are the phenotypic markers of Ig variable region genes, the data suggest that …