Heterotopic ossification (HO) is a diverse pathologic process, defined as the formation of
extraskeletal bone in muscle and soft tissues. HO can be conceptualized as a tissue repair …

Heterotopic ossification (HO) is a common occurrence after multiple forms of extensive
trauma. These include arthroplasties, traumatic brain and spinal cord injuries, extensive …

Fibrodysplasia ossificans progressiva (FOP) is a rare autosomal-dominant disorder
characterized by progressive and profoundly disabling heterotopic ossification (HO). Here …

Fibrodysplasia ossificans progressiva (FOP) is an ultra‐rare, severely disabling genetic
disorder of progressive heterotopic ossification (HO). The single‐arm, open‐label, phase 3 …

Fibrodysplasia ossificans progressiva (FOP) is a rare and intractable disease characterized
by extraskeletal bone formation through endochondral ossification. Patients with FOP harbor …

Heterotopic ossification (HO) is a clinical condition that often reduces mobility and
diminishes quality of life for affected individuals. The most severe form of progressive HO …

Much of the similarities of the tissue characteristics, pathologies and mechanisms of
heterotopic ossification (HO) formation are shared between HO of tendon and ligament …

The transforming growth factor β (TGF-β) family of signaling molecules, which includes TGF-
βs, activins, inhibins, and numerous bone morphogenetic proteins (BMPs) and growth and …

Abstract Transferrin receptor 2 (Tfr2) is mainly expressed in the liver and controls iron
homeostasis. Here, we identify Tfr2 as a regulator of bone homeostasis that inhibits bone …

Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease in which heterotopic
bone forms in muscle and soft tissue, leading to joint dysfunction and significant disability …