The SOS system: a complex and tightly regulated response to DNA damage
KH Maslowska, K Makiela‐Dzbenska… - Environmental and …, 2019 - Wiley Online Library
Genomes of all living organisms are constantly threatened by endogenous and exogenous
agents that challenge the chemical integrity of DNA. Most bacteria have evolved a …
agents that challenge the chemical integrity of DNA. Most bacteria have evolved a …
Escherichia coli DNA replication: the old model organism still holds many surprises
K Łazowski, R Woodgate… - FEMS Microbiology …, 2024 - academic.oup.com
Research on Escherichia coli DNA replication paved the groundwork for many breakthrough
discoveries with important implications for our understanding of human molecular biology …
discoveries with important implications for our understanding of human molecular biology …
Peptides containing the PCNA interacting motif APIM bind to the β-clamp and inhibit bacterial growth and mutagenesis
A Nedal, SB Ræder, B Dalhus, E Helgesen… - Nucleic Acids …, 2020 - academic.oup.com
In the fight against antimicrobial resistance, the bacterial DNA sliding clamp, β-clamp, is a
promising drug target for inhibition of DNA replication and translesion synthesis. The β …
promising drug target for inhibition of DNA replication and translesion synthesis. The β …
Distal mutations in the β-clamp of DNA polymerase III* disrupt DNA orientation and affect exonuclease activity
MB Berger, GA Cisneros - Journal of the American Chemical …, 2023 - ACS Publications
DNA polymerases are responsible for the replication and repair of DNA found in all DNA-
based organisms. DNA Polymerase III is the main replicative polymerase of E. coli and is …
based organisms. DNA Polymerase III is the main replicative polymerase of E. coli and is …
Exquisite selectivity of griselimycin extends to beta subunit of DNA polymerases from Gram-negative bacterial pathogens
MK Fenwick, PG Pierce, J Abendroth, KF Barrett… - Communications …, 2024 - nature.com
Griselimycin, a cyclic depsidecapeptide produced by Streptomyces griseus, is a promising
lead inhibitor of the sliding clamp component of bacterial DNA polymerases (β-subunit of …
lead inhibitor of the sliding clamp component of bacterial DNA polymerases (β-subunit of …
The Mutant βE202K Sliding Clamp Protein Impairs DNA Polymerase III Replication Activity
C Homiski, MK Scotland, VMP Babu… - Journal of …, 2021 - Am Soc Microbiol
Expression of the Escherichia coli dnaN-encoded β clamp at≥ 10-fold higher than
chromosomally expressed levels impedes growth by interfering with DNA replication. We …
chromosomally expressed levels impedes growth by interfering with DNA replication. We …
During translesion synthesis, Escherichia coli DinB89 (T120P) alters interactions of DinB (Pol IV) with Pol III subunit assemblies and SSB, but not with the β clamp
MK Scotland, C Homiski, MD Sutton - Journal of Bacteriology, 2022 - Am Soc Microbiol
Translesion synthesis (TLS) by specialized DNA polymerases (Pols) is an evolutionarily
conserved mechanism for tolerating replication-blocking DNA lesions. Using the Escherichia …
conserved mechanism for tolerating replication-blocking DNA lesions. Using the Escherichia …
Cloning and characterization of the major AP endonuclease from Staphylococcus aureus
A Turgimbayeva, U Zein, DO Zharkov, Y Ramankulov… - DNA repair, 2022 - Elsevier
Apurinic/apyrimidinic (AP) endonucleases are key enzymes involved in the repair of abasic
sites and DNA strand breaks. Complete genome analysis of Staphylococcus aureus …
sites and DNA strand breaks. Complete genome analysis of Staphylococcus aureus …
Seleção de inibidores da replicação do DNA de Staphylococcus aureus
RC Diniz, LCN da Silva, MM Costa… - Seven …, 2024 - sevenpublicacoes.com.br
CHAPTER 50 Selection of Staphylococcus aureus DNA replication inhibitors Page 1 Themes
focused on interdisciplinarity and sustainable development worldwide V. 02 Selection of …
focused on interdisciplinarity and sustainable development worldwide V. 02 Selection of …
In vivo demonstration of enhanced binding between β-clamp and DnaE of pol III bearing consensus i-CBM
AA Patoli, BB Patoli - Genes & genomics, 2019 - Springer
Background Among several key protein–protein and protein–DNA interactions within the
replisome, the interaction between β-clamp and the DNA polymerase (Pol) III is of crucial …
replisome, the interaction between β-clamp and the DNA polymerase (Pol) III is of crucial …