Recognized more than a decade ago, NKT cells differentiate from mainstream thymic
precursors through instructive signals emanating during TCR engagement by CD1d …

▪ Abstract Autoimmunity is a complex process that likely results from the summation of
multiple defective tolerance mechanisms. The NOD mouse strain is an excellent model of …

▪ Abstract This review summarizes the major features of CD1 genes and proteins, the
patterns of intracellular trafficking of CD1 molecules, and how they sample different …

The dynamics of CD4+ effector T cells (Teff cells) and CD4+ Foxp3+ regulatory T cells (Treg
cells) during diabetes progression in nonobese diabetic mice was investigated to determine …

CD1d-restricted natural killer (NK) T cells are known to potently secrete T helper (Th) 1 and
Th2 cytokines and to mediate cytolysis, but it is unclear how these contrasting functional …

Many characteristics distinguish CD1d-reactive natural killer T (NKT) cells that express the
invariant Vα14–Jα18 T-cell receptor (known here as Vα14 i T cells) from conventional T …

CD1d-restricted autoreactive natural killer (NK) T cells have been reported to regulate a
range of disease conditions, including type I diabetes and immune rejection of cancer …

A novel lymphocyte lineage, Vα14 natural killer T (NKT) cells, is now well established as
distinct from conventional αβ T cells. Vα14 NKT cells express a single invariant Vα14 …

Innate B and T lymphocytes are a subset of lymphocytes that express a restricted set of semi-
invariant, germ-line-encoded, autoreactive antigen receptors. Although they have long been …

Diabetes in non-obese diabetic (NOD) mice is mediated by pathogenic T-helper type 1 (Th1)
cells that arise because of a deficiency in regulatory or suppressor T cells,. Vα14–Jα15 …