Chlorinated tacrine analogs: Design, synthesis and biological evaluation of their anti-cholinesterase activity as potential treatment for Alzheimer's disease

HM Ragab, M Teleb, HR Haidar, N Gouda - Bioorganic chemistry, 2019 - Elsevier
In search of potent acetyl cholinesterase inhibitors with low hepatotoxicity for the treatment of
Alzheimer's disease, introduction of a chloro substitution to tacrine and some of its analogs …

Synthesis, biological evaluation and modeling of hybrids from tetrahydro-1H-pyrazolo [3, 4-b] quinolines as dual cholinestrase and COX-2 inhibitors

M Mroueh, WH Faour, WN Shebaby, CF Daher… - Bioorganic …, 2020 - Elsevier
Abstract New tetrahydro-1H-pyrazolo [3, 4-b] quinoline derivatives were designed,
synthesized and characterized as dual anticholinestrase and cyclooxygenase-2 inhibitors …

Recent Advancements and Developments in the Biological Importance of Pyrimido [4, 5‐b] Quinoline Scaffolds

MM Hammouda, MM Rashed… - …, 2024 - Wiley Online Library
This study highlights the biological efficiency of pyrimido [4, 5‐b] quinolines as inhibitors of
cancer cell growth and antioxidants and anti‐inflammatory properties, etc. Recent research …

Anti-leishmanial effect of spiro dihydroquinoline-oxindoles on volume regulation decrease and sterol biosynthesis of Leishmania braziliensis

J Leañez, J Nuñez, Y García-Marchan, F Sojo… - Experimental …, 2019 - Elsevier
Diverse spiro dihydroquinoline-oxindoles (JS series) were prepared using the BF 3• OEt 2-
catalyzed imino Diels-Alder reaction between ketimine-isatin derivatives and trans …

Poly N,N-dimethylaniline-formaldehyde supported on silica-coated magnetic nanoparticles: a novel and retrievable catalyst for green synthesis of 2-amino-3 …

S Asadbegi, MA Bodaghifard… - Research on Chemical …, 2020 - Springer
Preparation and application of novel and reusable magnetic nanoparticles with poly N, N-
dimethylaniline-formaldehyde support as a heterogeneous basic catalyst have been …

Microwave-assisted synthesis of 2, 3-dihydropyrido [2, 3-d] pyrimidin-4 (1 H)-ones catalyzed by DBU in aqueous medium

L Yang, D Shi, S Chen, H Chai, D Huang, Q Zhang… - Green chemistry, 2012 - pubs.rsc.org
A clean green, efficient and facile protocol was developed for the synthesis of a series of 2, 3-
dihydropyrido [2, 3-d] pyrimidin-4 (1H)-ones in water with good yield by the reaction of 2 …

Synthesis and antitumor screening of new series of pyrimido-[4,5-b]quinolines and [1,2,4]triazolo[2′,3′:3,4]pyrimido[6,5-b]quinolines

MB El-Ashmawy, MA El-Sherbeny… - Medicinal Chemistry …, 2013 - Springer
Abstract New series of pyrimido [4, 5-b] quinolines and [1, 2, 4] triazolo [2′, 3′: 3, 4]
pyrimido [6, 5-b] quinolines have been synthesized. Compounds 4a, 4e, 4f, 4h, 5b, 5d, 6a …

A convenient synthesis and molecular modeling study of novel purine and pyrimidine derivatives as CDK2/cyclin A3 inhibitors

ASSH Elgazwy, NSM Ismail, HSA Elzahabi - Bioorganic & medicinal …, 2010 - Elsevier
A series of novel purine and pyrimidine derivatives were prepared and biologically
evaluated for their in vitro anti-CDK2/cyclin A3 and antitumor activities in Ehrlich ascites …

[HTML][HTML] An efficient protocol for the one-pot multicomponent synthesis of polysubstituted pyridines by using a biopolymer-based magnetic nanocomposite

A Maleki, AA Jafari, S Yousefi… - Comptes …, 2015 - comptes-rendus.academie-sciences …
Résumé A biopolymer cellulose-based magnetic composite nanocatalyst was prepared and
characterized by using scanning electron microscopy (SEM) and energy dispersive X-ray …

Synthesis, antileishmanial and cytotoxicity activities of fused and nonfused tetrahydroquinoline derivatives

HMF Madkour, MAEAM El-Hashash, MS Salem… - Research on Chemical …, 2018 - Springer
Developing novel antileishmanial, and cytotoxic drugs has been a significant area in
modern pharmaceutical research. A series of novel triazolo [4, 3-a] quinoline, triazino [4, 3-a] …